node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC189 | CFAP221 | ENSP00000437532 | ENSP00000393222 | Coiled-coil domain containing 189. | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | 0.622 |
CCDC189 | DPY30 | ENSP00000437532 | ENSP00000345837 | Coiled-coil domain containing 189. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | 0.724 |
CCDC189 | LRGUK | ENSP00000437532 | ENSP00000285928 | Coiled-coil domain containing 189. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.861 |
CCDC189 | SPAG17 | ENSP00000437532 | ENSP00000337804 | Coiled-coil domain containing 189. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.697 |
CCDC189 | SPAG6 | ENSP00000437532 | ENSP00000365811 | Coiled-coil domain containing 189. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.461 |
CFAP221 | CCDC189 | ENSP00000393222 | ENSP00000437532 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Coiled-coil domain containing 189. | 0.622 |
CFAP221 | DPY30 | ENSP00000393222 | ENSP00000345837 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | 0.600 |
CFAP221 | KIAA1257 | ENSP00000393222 | ENSP00000265068 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Uncharacterized protein KIAA1257. | 0.591 |
CFAP221 | LRGUK | ENSP00000393222 | ENSP00000285928 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.849 |
CFAP221 | SPAG16 | ENSP00000393222 | ENSP00000332592 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity). | 0.485 |
CFAP221 | SPAG17 | ENSP00000393222 | ENSP00000337804 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.807 |
CFAP221 | SPAG6 | ENSP00000393222 | ENSP00000365811 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.801 |
CFAP221 | SPEF2 | ENSP00000393222 | ENSP00000348314 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.657 |
DNAI1 | EFCAB6 | ENSP00000480538 | ENSP00000262726 | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. | 0.733 |
DNAI1 | SPAG17 | ENSP00000480538 | ENSP00000337804 | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.724 |
DNAI1 | SPAG6 | ENSP00000480538 | ENSP00000365811 | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.653 |
DNAI1 | SPEF2 | ENSP00000480538 | ENSP00000348314 | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.708 |
DPY30 | CCDC189 | ENSP00000345837 | ENSP00000437532 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | Coiled-coil domain containing 189. | 0.724 |
DPY30 | CFAP221 | ENSP00000345837 | ENSP00000393222 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | 0.600 |
DPY30 | KIAA1257 | ENSP00000345837 | ENSP00000265068 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | Uncharacterized protein KIAA1257. | 0.496 |