node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD46 | SPRYD4 | ENSP00000429015 | ENSP00000338034 | Ankyrin repeat domain 46. | SPRY domain containing 4. | 0.433 |
C12orf71 | LYZL4 | ENSP00000413728 | ENSP00000287748 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | 0.518 |
C12orf71 | LYZL6 | ENSP00000413728 | ENSP00000483897 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6. | 0.531 |
C12orf71 | MIP | ENSP00000413728 | ENSP00000498622 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell- to-cell adhesion and facilitates gap junction coupling ; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.413 |
C12orf71 | SPRYD4 | ENSP00000413728 | ENSP00000338034 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | SPRY domain containing 4. | 0.527 |
DHODH | SPRYD4 | ENSP00000219240 | ENSP00000338034 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | SPRY domain containing 4. | 0.631 |
GLS2 | SPRYD4 | ENSP00000310447 | ENSP00000338034 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | SPRY domain containing 4. | 0.466 |
GTPBP8 | SPRYD4 | ENSP00000373176 | ENSP00000338034 | GTP binding protein 8. | SPRY domain containing 4. | 0.483 |
LYZL4 | C12orf71 | ENSP00000287748 | ENSP00000413728 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | 0.518 |
LYZL4 | SPRYD4 | ENSP00000287748 | ENSP00000338034 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | SPRY domain containing 4. | 0.432 |
LYZL6 | C12orf71 | ENSP00000483897 | ENSP00000413728 | Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6. | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | 0.531 |
LYZL6 | MIP | ENSP00000483897 | ENSP00000498622 | Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6. | Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell- to-cell adhesion and facilitates gap junction coupling ; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.403 |
LYZL6 | SPRYD4 | ENSP00000483897 | ENSP00000338034 | Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6. | SPRY domain containing 4. | 0.442 |
MIP | C12orf71 | ENSP00000498622 | ENSP00000413728 | Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell- to-cell adhesion and facilitates gap junction coupling ; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | 0.413 |
MIP | LYZL6 | ENSP00000498622 | ENSP00000483897 | Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell- to-cell adhesion and facilitates gap junction coupling ; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6. | 0.403 |
MIP | SPRYD4 | ENSP00000498622 | ENSP00000338034 | Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell- to-cell adhesion and facilitates gap junction coupling ; Belongs to the MIP/aquaporin (TC 1.A.8) family. | SPRY domain containing 4. | 0.471 |
SMCO3 | SPRYD4 | ENSP00000381895 | ENSP00000338034 | Single-pass membrane protein with coiled-coil domains 3. | SPRY domain containing 4. | 0.539 |
SPRYD4 | ANKRD46 | ENSP00000338034 | ENSP00000429015 | SPRY domain containing 4. | Ankyrin repeat domain 46. | 0.433 |
SPRYD4 | C12orf71 | ENSP00000338034 | ENSP00000413728 | SPRY domain containing 4. | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | 0.527 |
SPRYD4 | DHODH | ENSP00000338034 | ENSP00000219240 | SPRY domain containing 4. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.631 |