SPRYD4 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD46	SPRYD4	ENSP00000429015	ENSP00000338034	Ankyrin repeat domain 46.	SPRY domain containing 4.	0.497
C12orf71	LYZL4	ENSP00000413728	ENSP00000287748	Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71.	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	0.502
C12orf71	LYZL6	ENSP00000413728	ENSP00000483897	Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71.	Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6.	0.514
C12orf71	SPRYD4	ENSP00000413728	ENSP00000338034	Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71.	SPRY domain containing 4.	0.507
CLPP	SPRYD4	ENSP00000245816	ENSP00000338034	ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.	SPRY domain containing 4.	0.590
CRBN	SPRYD4	ENSP00000231948	ENSP00000338034	Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding [...]	SPRY domain containing 4.	0.498
EEF1B2	SPRYD4	ENSP00000376055	ENSP00000338034	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.	SPRY domain containing 4.	0.560
LYZL4	C12orf71	ENSP00000287748	ENSP00000413728	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71.	0.502
LYZL4	SPRYD4	ENSP00000287748	ENSP00000338034	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	SPRY domain containing 4.	0.551
LYZL6	C12orf71	ENSP00000483897	ENSP00000413728	Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6.	Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71.	0.514
LYZL6	SMCO3	ENSP00000483897	ENSP00000381895	Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6.	Single-pass membrane protein with coiled-coil domains 3.	0.402
LYZL6	SPRYD4	ENSP00000483897	ENSP00000338034	Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6.	SPRY domain containing 4.	0.563
SMCO3	LYZL6	ENSP00000381895	ENSP00000483897	Single-pass membrane protein with coiled-coil domains 3.	Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6.	0.402
SMCO3	SPRYD4	ENSP00000381895	ENSP00000338034	Single-pass membrane protein with coiled-coil domains 3.	SPRY domain containing 4.	0.516
SPPL2B	SPRYD4	ENSP00000478298	ENSP00000338034	Signal peptide peptidase-like 2B; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependen [...]	SPRY domain containing 4.	0.512
SPRYD4	ANKRD46	ENSP00000338034	ENSP00000429015	SPRY domain containing 4.	Ankyrin repeat domain 46.	0.497
SPRYD4	C12orf71	ENSP00000338034	ENSP00000413728	SPRY domain containing 4.	Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71.	0.507
SPRYD4	CLPP	ENSP00000338034	ENSP00000245816	SPRY domain containing 4.	ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.	0.590
SPRYD4	CRBN	ENSP00000338034	ENSP00000231948	SPRY domain containing 4.	Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding [...]	0.498
SPRYD4	EEF1B2	ENSP00000338034	ENSP00000376055	SPRY domain containing 4.	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.	0.560