STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM217Transmembrane protein 217 (229 aa)    
Predicted Functional Partners:
PLEKHO2
Pleckstrin homology domain containing O2
      
 0.611
C2orf66
Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66
      
 0.570
SLC46A3
Solute carrier family 46 member 3; Belongs to the major facilitator superfamily. SLC46A family
      
 0.565
PLEKHH1
Pleckstrin homology, MyTH4 and FERM domain containing H1
      
 0.561
C1orf110
Coiled-coil domain-containing protein 190; Chromosome 1 open reading frame 110
      
 0.556
SLC37A2
Glucose-6-phosphate exchanger SLC37A2; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6- phosphatase. May not play a role in homeostatic regulation of blood glucose levels; Solute carriers
      
 0.535
SLC26A8
Testis anion transporter 1; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes [...]
      
 0.533
TMEM174
Transmembrane protein 174
      
 0.532
ZNF600
Zinc finger protein 600; May be involved in transcriptional regulation; Zinc fingers C2H2-type
      
 0.530
MRPL14
39S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable); Mitochondrial ribosomal proteins
      
 0.527
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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