TMEM39B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX39A	TMEM39B	ENSP00000242776	ENSP00000338165	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	Transmembrane protein 39B; Belongs to the TMEM39 family.	0.476
DNAJC18	FAM118A	ENSP00000302843	ENSP00000216214	DnaJ heat shock protein family member C18.	Protein FAM118A; Family with sequence similarity 118 member A.	0.485
DNAJC18	LETM2	ENSP00000302843	ENSP00000369291	DnaJ heat shock protein family member C18.	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.	0.511
DNAJC18	REEP6	ENSP00000302843	ENSP00000233596	DnaJ heat shock protein family member C18.	Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).	0.450
DNAJC18	RHBDD3	ENSP00000302843	ENSP00000216085	DnaJ heat shock protein family member C18.	Rhomboid domain containing 3.	0.458
DNAJC18	TMEM39B	ENSP00000302843	ENSP00000338165	DnaJ heat shock protein family member C18.	Transmembrane protein 39B; Belongs to the TMEM39 family.	0.441
FAM118A	DNAJC18	ENSP00000216214	ENSP00000302843	Protein FAM118A; Family with sequence similarity 118 member A.	DnaJ heat shock protein family member C18.	0.485
FAM118A	LETM2	ENSP00000216214	ENSP00000369291	Protein FAM118A; Family with sequence similarity 118 member A.	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.	0.483
FAM118A	REEP6	ENSP00000216214	ENSP00000233596	Protein FAM118A; Family with sequence similarity 118 member A.	Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).	0.442
FAM118A	RHBDD3	ENSP00000216214	ENSP00000216085	Protein FAM118A; Family with sequence similarity 118 member A.	Rhomboid domain containing 3.	0.512
FAM118A	TMEM39B	ENSP00000216214	ENSP00000338165	Protein FAM118A; Family with sequence similarity 118 member A.	Transmembrane protein 39B; Belongs to the TMEM39 family.	0.510
ISLR	TMEM39B	ENSP00000249842	ENSP00000338165	Immunoglobulin superfamily containing leucine rich repeat.	Transmembrane protein 39B; Belongs to the TMEM39 family.	0.543
LETM2	DNAJC18	ENSP00000369291	ENSP00000302843	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.	DnaJ heat shock protein family member C18.	0.511
LETM2	FAM118A	ENSP00000369291	ENSP00000216214	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.	Protein FAM118A; Family with sequence similarity 118 member A.	0.483
LETM2	REEP6	ENSP00000369291	ENSP00000233596	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.	Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).	0.446
LETM2	RHBDD3	ENSP00000369291	ENSP00000216085	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.	Rhomboid domain containing 3.	0.460
LETM2	TMEM39B	ENSP00000369291	ENSP00000338165	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.	Transmembrane protein 39B; Belongs to the TMEM39 family.	0.436
NRG1	TMEM39B	ENSP00000287842	ENSP00000338165	Pro-neuregulin-1, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gla [...]	Transmembrane protein 39B; Belongs to the TMEM39 family.	0.496
PLD6	TMEM39B	ENSP00000317177	ENSP00000338165	Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Al [...]	Transmembrane protein 39B; Belongs to the TMEM39 family.	0.438
REEP6	DNAJC18	ENSP00000233596	ENSP00000302843	Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).	DnaJ heat shock protein family member C18.	0.450