close STRING Data Update
The upcoming version of STRING is available for preview: it includes new data, new enrichment categories (e.g. diseases and tissues) and covers 14000 fully sequenced genomes.
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAQR6Membrane progestin receptor delta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Belongs to the ADIPOR family (351 aa)    
Predicted Functional Partners:
PAQR9
Membrane progestin receptor epsilon; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Progestin and adipoQ receptor family
      
 0.842
PAQR7
Membrane progestin receptor alpha; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Belongs to the ADIPOR family
      
 0.762
C1orf110
Coiled-coil domain-containing protein 190; Chromosome 1 open reading frame 110
      
 0.721
PGRMC2
Membrane-associated progesterone receptor component 2; Receptor for steroids; Membrane associated progesterone receptor family
      
 0.630
SOX14
Transcription factor SOX-14; Acts as a negative regulator of transcription; SRY-boxes
      
 0.599
PGRMC1
Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs); Belongs to the cytochrome b5 family. MAPR subfamily
      
 0.597
PAQR3
Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family
      
 0.572
ADIPOQ
Adiponectin; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis [...]
      
 0.560
CYB5D2
Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family
      
 0.559
PAQR4
Progestin and adipoQ receptor family member 4
   
  
 0.553
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (16%) [HD]