FNDC3B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FNDC3A	FNDC3B	ENSP00000441831	ENSP00000411242	Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. Belongs to the FNDC3 family.	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	0.635
FNDC3A	TENT5A	ENSP00000441831	ENSP00000318298	Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. Belongs to the FNDC3 family.	Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase.	0.712
FNDC3B	FNDC3A	ENSP00000411242	ENSP00000441831	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. Belongs to the FNDC3 family.	0.635
FNDC3B	IGF2BP3	ENSP00000411242	ENSP00000258729	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Insulin-like growth factor 2 mRNA-binding protein 3; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Bind [...]	0.570
FNDC3B	MPDZ	ENSP00000411242	ENSP00000320006	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.	0.527
FNDC3B	RBFOX2	ENSP00000411242	ENSP00000413035	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.	0.615
FNDC3B	SPINT2	ENSP00000411242	ENSP00000301244	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Kunitz-type protease inhibitor 2; Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.	0.530
FNDC3B	TENT5A	ENSP00000411242	ENSP00000318298	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase.	0.723
FNDC3B	TMCO1	ENSP00000411242	ENSP00000480514	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store.	0.563
FNDC3B	TOX4	ENSP00000411242	ENSP00000477868	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.	0.548
FNDC3B	TRIP13	ENSP00000411242	ENSP00000166345	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...]	0.827
FNDC3B	ZNF469	ENSP00000411242	ENSP00000456500	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	Zinc finger protein 469; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.581
IGF2BP3	FNDC3B	ENSP00000258729	ENSP00000411242	Insulin-like growth factor 2 mRNA-binding protein 3; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Bind [...]	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	0.570
MPDZ	FNDC3B	ENSP00000320006	ENSP00000411242	Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	0.527
MPDZ	ZNF469	ENSP00000320006	ENSP00000456500	Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.	Zinc finger protein 469; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.570
RBFOX2	FNDC3B	ENSP00000413035	ENSP00000411242	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	0.615
SPINT2	FNDC3B	ENSP00000301244	ENSP00000411242	Kunitz-type protease inhibitor 2; Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	0.530
TENT5A	FNDC3A	ENSP00000318298	ENSP00000441831	Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase.	Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. Belongs to the FNDC3 family.	0.712
TENT5A	FNDC3B	ENSP00000318298	ENSP00000411242	Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase.	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	0.723
TMCO1	FNDC3B	ENSP00000480514	ENSP00000411242	Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store.	Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.	0.563