node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNIH3 | FAM53B | ENSP00000272133 | ENSP00000338532 | Protein cornichon homolog 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Belongs to the cornichon family. | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 0.550 |
CYFIP2 | FAM53B | ENSP00000479719 | ENSP00000338532 | Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 0.462 |
CYFIP2 | YWHAZ | ENSP00000479719 | ENSP00000379287 | Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Belongs to the 14-3-3 family. | 0.454 |
FAM53B | CNIH3 | ENSP00000338532 | ENSP00000272133 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | Protein cornichon homolog 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Belongs to the cornichon family. | 0.550 |
FAM53B | CYFIP2 | ENSP00000338532 | ENSP00000479719 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). | 0.462 |
FAM53B | KLK4 | ENSP00000338532 | ENSP00000326159 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). | 0.444 |
FAM53B | MMP13 | ENSP00000338532 | ENSP00000260302 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.407 |
FAM53B | SFN | ENSP00000338532 | ENSP00000340989 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. | 0.612 |
FAM53B | SNW1 | ENSP00000338532 | ENSP00000451129 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] | 0.510 |
FAM53B | YWHAE | ENSP00000338532 | ENSP00000264335 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. | 0.595 |
FAM53B | YWHAZ | ENSP00000338532 | ENSP00000379287 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Belongs to the 14-3-3 family. | 0.556 |
FAM53B | ZNF646 | ENSP00000338532 | ENSP00000300850 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | Zinc finger protein 646; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.448 |
FAM53B | ZXDC | ENSP00000338532 | ENSP00000374359 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | Zinc finger protein ZXDC; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Belongs to the ZXD family. | 0.483 |
KLK4 | FAM53B | ENSP00000326159 | ENSP00000338532 | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 0.444 |
MMP13 | FAM53B | ENSP00000260302 | ENSP00000338532 | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 0.407 |
SFN | FAM53B | ENSP00000340989 | ENSP00000338532 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 0.612 |
SFN | YWHAE | ENSP00000340989 | ENSP00000264335 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. | 0.737 |
SFN | YWHAZ | ENSP00000340989 | ENSP00000379287 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Belongs to the 14-3-3 family. | 0.878 |
SNW1 | FAM53B | ENSP00000451129 | ENSP00000338532 | SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 0.510 |
YWHAE | FAM53B | ENSP00000264335 | ENSP00000338532 | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. | 0.595 |