node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN7L2 | ZNF212 | ENSP00000358886 | ENSP00000338572 | Ataxin-7-like protein 2; Ataxin 7 like 2. | Zinc finger protein 212; May be involved in transcriptional regulation. | 0.651 |
GNB2 | TRIM28 | ENSP00000305260 | ENSP00000253024 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.459 |
GNB2 | ZNF212 | ENSP00000305260 | ENSP00000338572 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Zinc finger protein 212; May be involved in transcriptional regulation. | 0.570 |
SF3A3 | ZNF212 | ENSP00000362110 | ENSP00000338572 | Splicing factor 3A subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. | Zinc finger protein 212; May be involved in transcriptional regulation. | 0.589 |
TRIM28 | GNB2 | ENSP00000253024 | ENSP00000305260 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.459 |
TRIM28 | ZNF212 | ENSP00000253024 | ENSP00000338572 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 212; May be involved in transcriptional regulation. | 0.687 |
TRIM28 | ZNF282 | ENSP00000253024 | ENSP00000477841 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'- TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.732 |
TRIM28 | ZNF398 | ENSP00000253024 | ENSP00000420418 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 398; Functions as a transcriptional activator. | 0.607 |
TRIM28 | ZNF746 | ENSP00000253024 | ENSP00000493970 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 746; Transcription repressor that specifically binds to the 5'- TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. | 0.905 |
TRIM28 | ZNF777 | ENSP00000253024 | ENSP00000247930 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 777; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.617 |
ZNF212 | ATXN7L2 | ENSP00000338572 | ENSP00000358886 | Zinc finger protein 212; May be involved in transcriptional regulation. | Ataxin-7-like protein 2; Ataxin 7 like 2. | 0.651 |
ZNF212 | GNB2 | ENSP00000338572 | ENSP00000305260 | Zinc finger protein 212; May be involved in transcriptional regulation. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.570 |
ZNF212 | SF3A3 | ENSP00000338572 | ENSP00000362110 | Zinc finger protein 212; May be involved in transcriptional regulation. | Splicing factor 3A subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. | 0.589 |
ZNF212 | TRIM28 | ENSP00000338572 | ENSP00000253024 | Zinc finger protein 212; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.687 |
ZNF212 | ZNF282 | ENSP00000338572 | ENSP00000477841 | Zinc finger protein 212; May be involved in transcriptional regulation. | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'- TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.840 |
ZNF212 | ZNF398 | ENSP00000338572 | ENSP00000420418 | Zinc finger protein 212; May be involved in transcriptional regulation. | Zinc finger protein 398; Functions as a transcriptional activator. | 0.829 |
ZNF212 | ZNF408 | ENSP00000338572 | ENSP00000309606 | Zinc finger protein 212; May be involved in transcriptional regulation. | Zinc finger protein 408; May be involved in transcriptional regulation. | 0.707 |
ZNF212 | ZNF746 | ENSP00000338572 | ENSP00000493970 | Zinc finger protein 212; May be involved in transcriptional regulation. | Zinc finger protein 746; Transcription repressor that specifically binds to the 5'- TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. | 0.837 |
ZNF212 | ZNF777 | ENSP00000338572 | ENSP00000247930 | Zinc finger protein 212; May be involved in transcriptional regulation. | Zinc finger protein 777; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.717 |
ZNF212 | ZNF783 | ENSP00000338572 | ENSP00000410890 | Zinc finger protein 212; May be involved in transcriptional regulation. | Protein ZNF783; May be involved in transcriptional regulation. | 0.725 |