node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BFSP2 | CRYAA | ENSP00000304987 | ENSP00000291554 | Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. | 0.743 |
BFSP2 | CRYGN | ENSP00000304987 | ENSP00000338613 | Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Crystallin gamma N. | 0.559 |
BFSP2 | GRIFIN | ENSP00000304987 | ENSP00000481185 | Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Grifin; Galectin-related inter-fiber protein. | 0.489 |
BFSP2 | LGSN | ENSP00000304987 | ENSP00000359691 | Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.579 |
CRYAA | BFSP2 | ENSP00000291554 | ENSP00000304987 | Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. | Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | 0.743 |
CRYAA | CRYGN | ENSP00000291554 | ENSP00000338613 | Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. | Crystallin gamma N. | 0.583 |
CRYAA | GRIFIN | ENSP00000291554 | ENSP00000481185 | Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. | Grifin; Galectin-related inter-fiber protein. | 0.412 |
CRYAA | LGSN | ENSP00000291554 | ENSP00000359691 | Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.480 |
CRYGN | BFSP2 | ENSP00000338613 | ENSP00000304987 | Crystallin gamma N. | Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | 0.559 |
CRYGN | CRYAA | ENSP00000338613 | ENSP00000291554 | Crystallin gamma N. | Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. | 0.583 |
CRYGN | GRIFIN | ENSP00000338613 | ENSP00000481185 | Crystallin gamma N. | Grifin; Galectin-related inter-fiber protein. | 0.590 |
CRYGN | ITSN1 | ENSP00000338613 | ENSP00000370719 | Crystallin gamma N. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | 0.535 |
CRYGN | ITSN2 | ENSP00000338613 | ENSP00000347244 | Crystallin gamma N. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.540 |
CRYGN | LGSN | ENSP00000338613 | ENSP00000359691 | Crystallin gamma N. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.527 |
CRYGN | RHEB | ENSP00000338613 | ENSP00000262187 | Crystallin gamma N. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. | 0.739 |
CRYGN | TSC1 | ENSP00000338613 | ENSP00000298552 | Crystallin gamma N. | Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co- chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 [...] | 0.688 |
CRYGN | TSC2 | ENSP00000338613 | ENSP00000219476 | Crystallin gamma N. | Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). | 0.745 |
CRYGN | WDR86 | ENSP00000338613 | ENSP00000419162 | Crystallin gamma N. | WD repeat domain 86. | 0.518 |
GRIFIN | BFSP2 | ENSP00000481185 | ENSP00000304987 | Grifin; Galectin-related inter-fiber protein. | Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. | 0.489 |
GRIFIN | CRYAA | ENSP00000481185 | ENSP00000291554 | Grifin; Galectin-related inter-fiber protein. | Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. | 0.412 |