BRIX1 protein (human) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

BRIX1

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. (353 aa)

Predicted Functional Partners:

NIP7

0.999

NIFK

0.999

EBNA1BP2

0.999

WDR12

0.998

GTPBP4

0.998

DDX18

0.997

MAK16

0.997

RPF1

0.997

NOC3L

0.997

MRTO4

0.997

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIX1	DDX18	ENSP00000338862	ENSP00000263239	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	0.997
BRIX1	EBNA1BP2	ENSP00000338862	ENSP00000407323	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA.	0.999
BRIX1	GTPBP4	ENSP00000338862	ENSP00000354040	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.998
BRIX1	MAK16	ENSP00000338862	ENSP00000353246	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	MAK16 homolog.	0.997
BRIX1	MRTO4	ENSP00000338862	ENSP00000364320	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.997
BRIX1	NIFK	ENSP00000338862	ENSP00000285814	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	Nucleolar protein interacting with the FHA domain of MKI67.	0.999
BRIX1	NIP7	ENSP00000338862	ENSP00000254940	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.999
BRIX1	NOC3L	ENSP00000338862	ENSP00000360412	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	Nucleolar complex protein 3 homolog; May be required for adipogenesis.	0.997
BRIX1	RPF1	ENSP00000338862	ENSP00000359688	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	Ribosome production factor 1; May be required for ribosome biogenesis.	0.997
BRIX1	WDR12	ENSP00000338862	ENSP00000261015	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.998
DDX18	BRIX1	ENSP00000263239	ENSP00000338862	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.	0.997
DDX18	EBNA1BP2	ENSP00000263239	ENSP00000407323	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA.	0.990
DDX18	GTPBP4	ENSP00000263239	ENSP00000354040	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.997
DDX18	MAK16	ENSP00000263239	ENSP00000353246	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	MAK16 homolog.	0.994
DDX18	MRTO4	ENSP00000263239	ENSP00000364320	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.996
DDX18	NIFK	ENSP00000263239	ENSP00000285814	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	Nucleolar protein interacting with the FHA domain of MKI67.	0.999
DDX18	NIP7	ENSP00000263239	ENSP00000254940	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.993
DDX18	NOC3L	ENSP00000263239	ENSP00000360412	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	Nucleolar complex protein 3 homolog; May be required for adipogenesis.	0.985
DDX18	RPF1	ENSP00000263239	ENSP00000359688	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	Ribosome production factor 1; May be required for ribosome biogenesis.	0.989
DDX18	WDR12	ENSP00000263239	ENSP00000261015	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.997