node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABRA | ACTA1 | ENSP00000311436 | ENSP00000355645 | Actin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | 0.402 |
ABRA | MRTFB | ENSP00000311436 | ENSP00000459626 | Actin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | 0.533 |
ABRA | SRF | ENSP00000311436 | ENSP00000265354 | Actin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required f [...] | 0.665 |
ACTA1 | ABRA | ENSP00000355645 | ENSP00000311436 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Actin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. | 0.402 |
ACTA1 | MRTFB | ENSP00000355645 | ENSP00000459626 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | 0.914 |
ACTA1 | PHACTR1 | ENSP00000355645 | ENSP00000329880 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). | 0.930 |
BACH2 | MRTFB | ENSP00000257749 | ENSP00000459626 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation ; Belongs to the bZI [...] | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | 0.540 |
C11orf95 | MRTFB | ENSP00000482180 | ENSP00000459626 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | 0.675 |
MAMSTR | MRTFB | ENSP00000324175 | ENSP00000459626 | MEF2-activating motif and SAP domain-containing transcriptional regulator; Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity). | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | 0.471 |
MAMSTR | SRF | ENSP00000324175 | ENSP00000265354 | MEF2-activating motif and SAP domain-containing transcriptional regulator; Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity). | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required f [...] | 0.588 |
MRTFB | ABRA | ENSP00000459626 | ENSP00000311436 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Actin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. | 0.533 |
MRTFB | ACTA1 | ENSP00000459626 | ENSP00000355645 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | 0.914 |
MRTFB | BACH2 | ENSP00000459626 | ENSP00000257749 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation ; Belongs to the bZI [...] | 0.540 |
MRTFB | C11orf95 | ENSP00000459626 | ENSP00000482180 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | 0.675 |
MRTFB | MAMSTR | ENSP00000459626 | ENSP00000324175 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | MEF2-activating motif and SAP domain-containing transcriptional regulator; Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity). | 0.471 |
MRTFB | PHACTR1 | ENSP00000459626 | ENSP00000329880 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). | 0.944 |
MRTFB | RBM15 | ENSP00000459626 | ENSP00000358799 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | RNA-binding protein 15; RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM [...] | 0.749 |
MRTFB | RHOA | ENSP00000459626 | ENSP00000400175 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.806 |
MRTFB | SRF | ENSP00000459626 | ENSP00000265354 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required f [...] | 0.978 |
MRTFB | STK38L | ENSP00000459626 | ENSP00000373684 | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.525 |