node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASTOR3 | GAD1 | ENSP00000389760 | ENSP00000350928 | CASTOR family member 3; Belongs to the GATS family. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.552 |
CASTOR3 | GAD2 | ENSP00000389760 | ENSP00000365437 | CASTOR family member 3; Belongs to the GATS family. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.601 |
CASTOR3 | SLC1A2 | ENSP00000389760 | ENSP00000278379 | CASTOR family member 3; Belongs to the GATS family. | Excitatory amino acid transporter 2; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminatin [...] | 0.425 |
CASTOR3 | SLC32A1 | ENSP00000389760 | ENSP00000217420 | CASTOR family member 3; Belongs to the GATS family. | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles. | 0.607 |
CASTOR3 | SLC6A11 | ENSP00000389760 | ENSP00000254488 | CASTOR family member 3; Belongs to the GATS family. | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. | 0.876 |
CASTOR3 | SLC6A13 | ENSP00000389760 | ENSP00000339260 | CASTOR family member 3; Belongs to the GATS family. | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport. | 0.883 |
GABRA5 | GABRD | ENSP00000382953 | ENSP00000367848 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | 0.747 |
GABRA5 | GAD1 | ENSP00000382953 | ENSP00000350928 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.585 |
GABRA5 | GAD2 | ENSP00000382953 | ENSP00000365437 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.540 |
GABRA5 | SLC32A1 | ENSP00000382953 | ENSP00000217420 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles. | 0.501 |
GABRA5 | SLC6A11 | ENSP00000382953 | ENSP00000254488 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. | 0.752 |
GABRA5 | SLC6A13 | ENSP00000382953 | ENSP00000339260 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport. | 0.816 |
GABRD | GABRA5 | ENSP00000367848 | ENSP00000382953 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | 0.747 |
GABRD | GAD1 | ENSP00000367848 | ENSP00000350928 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.537 |
GABRD | GAD2 | ENSP00000367848 | ENSP00000365437 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.468 |
GABRD | SLC32A1 | ENSP00000367848 | ENSP00000217420 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles. | 0.560 |
GABRD | SLC6A11 | ENSP00000367848 | ENSP00000254488 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. | 0.757 |
GABRD | SLC6A13 | ENSP00000367848 | ENSP00000339260 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport. | 0.818 |
GAD1 | CASTOR3 | ENSP00000350928 | ENSP00000389760 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | CASTOR family member 3; Belongs to the GATS family. | 0.552 |
GAD1 | GABRA5 | ENSP00000350928 | ENSP00000382953 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | 0.585 |