| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLC | LGALS1 | ENSP00000221804 | ENSP00000215909 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | 0.499 |
| CLC | LGALS12 | ENSP00000221804 | ENSP00000339374 | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | 0.704 |
| ECEL1 | LGALS12 | ENSP00000302051 | ENSP00000339374 | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | 0.417 |
| EMB | LGALS12 | ENSP00000302289 | ENSP00000339374 | Embigin; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | 0.654 |
| LGALS1 | CLC | ENSP00000215909 | ENSP00000221804 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | 0.499 |
| LGALS1 | LGALS12 | ENSP00000215909 | ENSP00000339374 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | 0.467 |
| LGALS1 | LGALS13 | ENSP00000215909 | ENSP00000221797 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes. | 0.563 |
| LGALS1 | LGALS16 | ENSP00000215909 | ENSP00000375904 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis. | 0.521 |
| LGALS12 | CLC | ENSP00000339374 | ENSP00000221804 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). | 0.704 |
| LGALS12 | ECEL1 | ENSP00000339374 | ENSP00000302051 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. | 0.417 |
| LGALS12 | EMB | ENSP00000339374 | ENSP00000302289 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Embigin; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). | 0.654 |
| LGALS12 | LGALS1 | ENSP00000339374 | ENSP00000215909 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | 0.467 |
| LGALS12 | LGALS13 | ENSP00000339374 | ENSP00000221797 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes. | 0.701 |
| LGALS12 | LGALS16 | ENSP00000339374 | ENSP00000375904 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis. | 0.471 |
| LGALS12 | LIMD1 | ENSP00000339374 | ENSP00000273317 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | LIM domain-containing protein 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts [...] | 0.628 |
| LGALS12 | PLIN1 | ENSP00000339374 | ENSP00000300055 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. | 0.534 |
| LGALS12 | TRARG1 | ENSP00000339374 | ENSP00000329548 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. | 0.453 |
| LGALS12 | VPS13C | ENSP00000339374 | ENSP00000493560 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization. | 0.839 |
| LGALS13 | LGALS1 | ENSP00000221797 | ENSP00000215909 | Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes. | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | 0.563 |
| LGALS13 | LGALS12 | ENSP00000221797 | ENSP00000339374 | Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes. | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. | 0.701 |
