node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDOB | ENO1 | ENSP00000497767 | ENSP00000495530 | Aldolase, fructose-bisphosphate B. | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | 0.936 |
ALDOB | ENO2 | ENSP00000497767 | ENSP00000437402 | Aldolase, fructose-bisphosphate B. | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium- dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). | 0.915 |
ALDOB | ENO3 | ENSP00000497767 | ENSP00000324105 | Aldolase, fructose-bisphosphate B. | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.932 |
ALDOB | ENO4 | ENSP00000497767 | ENSP00000345555 | Aldolase, fructose-bisphosphate B. | Enolase 4; May be required for sperm motility and function. | 0.909 |
ALDOB | GPI | ENSP00000497767 | ENSP00000405573 | Aldolase, fructose-bisphosphate B. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. | 0.970 |
ALDOB | LDHA | ENSP00000497767 | ENSP00000445175 | Aldolase, fructose-bisphosphate B. | Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family. | 0.906 |
ALDOB | LDHAL6A | ENSP00000497767 | ENSP00000280706 | Aldolase, fructose-bisphosphate B. | L-lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed. | 0.889 |
ALDOB | LDHAL6B | ENSP00000497767 | ENSP00000302393 | Aldolase, fructose-bisphosphate B. | Lactate dehydrogenase A like 6B. | 0.893 |
ALDOB | LDHC | ENSP00000497767 | ENSP00000437783 | Aldolase, fructose-bisphosphate B. | L-lactate dehydrogenase C chain; Possible role in sperm motility. | 0.892 |
ALDOB | PKLR | ENSP00000497767 | ENSP00000339933 | Aldolase, fructose-bisphosphate B. | Pyruvate kinase PKLR; Plays a key role in glycolysis. | 0.973 |
ENO1 | ALDOB | ENSP00000495530 | ENSP00000497767 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Aldolase, fructose-bisphosphate B. | 0.936 |
ENO1 | ENO2 | ENSP00000495530 | ENSP00000437402 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium- dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). | 0.954 |
ENO1 | ENO3 | ENSP00000495530 | ENSP00000324105 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.925 |
ENO1 | ENO4 | ENSP00000495530 | ENSP00000345555 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Enolase 4; May be required for sperm motility and function. | 0.697 |
ENO1 | GPI | ENSP00000495530 | ENSP00000405573 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. | 0.994 |
ENO1 | LDHA | ENSP00000495530 | ENSP00000445175 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family. | 0.924 |
ENO1 | LDHAL6A | ENSP00000495530 | ENSP00000280706 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | L-lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed. | 0.618 |
ENO1 | LDHAL6B | ENSP00000495530 | ENSP00000302393 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Lactate dehydrogenase A like 6B. | 0.616 |
ENO1 | LDHC | ENSP00000495530 | ENSP00000437783 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | L-lactate dehydrogenase C chain; Possible role in sperm motility. | 0.641 |
ENO1 | PKLR | ENSP00000495530 | ENSP00000339933 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Pyruvate kinase PKLR; Plays a key role in glycolysis. | 0.983 |