node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCAF5 | ZNF564 | ENSP00000341351 | ENSP00000340004 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.455 |
PPP1R16B | ZNF564 | ENSP00000299824 | ENSP00000340004 | Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cel [...] | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.443 |
SLC2A4RG | ZNF564 | ENSP00000266077 | ENSP00000340004 | SLC2A4 regulator; Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'. | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.411 |
TRAPPC6B | ZNF564 | ENSP00000330289 | ENSP00000340004 | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.445 |
TRIM28 | ZNF564 | ENSP00000253024 | ENSP00000340004 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.580 |
TRIM28 | ZNF701 | ENSP00000253024 | ENSP00000444339 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.615 |
TRIM28 | ZNF799 | ENSP00000253024 | ENSP00000411084 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 799; May be involved in transcriptional regulation. | 0.585 |
YPEL1 | ZNF564 | ENSP00000342832 | ENSP00000340004 | Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts; Belongs to the yippee family. | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.436 |
ZNF564 | DCAF5 | ENSP00000340004 | ENSP00000341351 | Zinc finger protein 564; May be involved in transcriptional regulation. | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | 0.455 |
ZNF564 | PPP1R16B | ENSP00000340004 | ENSP00000299824 | Zinc finger protein 564; May be involved in transcriptional regulation. | Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cel [...] | 0.443 |
ZNF564 | SLC2A4RG | ENSP00000340004 | ENSP00000266077 | Zinc finger protein 564; May be involved in transcriptional regulation. | SLC2A4 regulator; Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'. | 0.411 |
ZNF564 | TRAPPC6B | ENSP00000340004 | ENSP00000330289 | Zinc finger protein 564; May be involved in transcriptional regulation. | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). | 0.445 |
ZNF564 | TRIM28 | ENSP00000340004 | ENSP00000253024 | Zinc finger protein 564; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.580 |
ZNF564 | YPEL1 | ENSP00000340004 | ENSP00000342832 | Zinc finger protein 564; May be involved in transcriptional regulation. | Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts; Belongs to the yippee family. | 0.436 |
ZNF564 | ZNF701 | ENSP00000340004 | ENSP00000444339 | Zinc finger protein 564; May be involved in transcriptional regulation. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.484 |
ZNF564 | ZNF799 | ENSP00000340004 | ENSP00000411084 | Zinc finger protein 564; May be involved in transcriptional regulation. | Zinc finger protein 799; May be involved in transcriptional regulation. | 0.460 |
ZNF701 | TRIM28 | ENSP00000444339 | ENSP00000253024 | Zinc finger protein 701; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.615 |
ZNF701 | ZNF564 | ENSP00000444339 | ENSP00000340004 | Zinc finger protein 701; May be involved in transcriptional regulation. | Zinc finger protein 564; May be involved in transcriptional regulation. | 0.484 |
ZNF701 | ZNF799 | ENSP00000444339 | ENSP00000411084 | Zinc finger protein 701; May be involved in transcriptional regulation. | Zinc finger protein 799; May be involved in transcriptional regulation. | 0.401 |
ZNF799 | TRIM28 | ENSP00000411084 | ENSP00000253024 | Zinc finger protein 799; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.585 |