| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DCLK2 | KLHL36 | ENSP00000303887 | ENSP00000456743 | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.571 |
| DCLK2 | SLC15A5 | ENSP00000303887 | ENSP00000340402 | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.442 |
| KLHL36 | DCLK2 | ENSP00000456743 | ENSP00000303887 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). | 0.571 |
| KLHL36 | SLC15A5 | ENSP00000456743 | ENSP00000340402 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.547 |
| MAGI2 | MAST2 | ENSP00000346151 | ENSP00000354671 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.833 |
| MAGI2 | SLC15A5 | ENSP00000346151 | ENSP00000340402 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.508 |
| MAST2 | MAGI2 | ENSP00000354671 | ENSP00000346151 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. | 0.833 |
| MAST2 | SLC15A5 | ENSP00000354671 | ENSP00000340402 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.508 |
| NADK | SLC15A5 | ENSP00000367890 | ENSP00000340402 | NAD kinase; Belongs to the NAD kinase family. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.485 |
| PDZRN4 | SLC15A5 | ENSP00000384197 | ENSP00000340402 | PDZ domain containing ring finger 4. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.508 |
| SCRIB | SLC15A5 | ENSP00000349486 | ENSP00000340402 | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicle [...] | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.751 |
| SLC13A2 | SLC15A5 | ENSP00000392411 | ENSP00000340402 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.733 |
| SLC13A3 | SLC15A5 | ENSP00000279027 | ENSP00000340402 | Solute carrier family 13 member 3; High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate. The stoichiometry is probably 3 Na(+) for 1 divalent succinate. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.738 |
| SLC13A5 | SLC15A5 | ENSP00000406220 | ENSP00000340402 | Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.944 |
| SLC15A5 | DCLK2 | ENSP00000340402 | ENSP00000303887 | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). | 0.442 |
| SLC15A5 | KLHL36 | ENSP00000340402 | ENSP00000456743 | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.547 |
| SLC15A5 | MAGI2 | ENSP00000340402 | ENSP00000346151 | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. | 0.508 |
| SLC15A5 | MAST2 | ENSP00000340402 | ENSP00000354671 | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.508 |
| SLC15A5 | NADK | ENSP00000340402 | ENSP00000367890 | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | NAD kinase; Belongs to the NAD kinase family. | 0.485 |
| SLC15A5 | PDZRN4 | ENSP00000340402 | ENSP00000384197 | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | PDZ domain containing ring finger 4. | 0.508 |
