node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL7 | FAU | ENSP00000438788 | ENSP00000431822 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.992 |
CUL7 | MRPL2 | ENSP00000438788 | ENSP00000373404 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 0.451 |
CUL7 | RPL21 | ENSP00000438788 | ENSP00000346027 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | 0.973 |
CUL7 | YWHAE | ENSP00000438788 | ENSP00000264335 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. | 0.482 |
CUL7 | ZNF395 | ENSP00000438788 | ENSP00000340494 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Zinc finger protein 395; Plays a role in papillomavirus genes transcription. | 0.548 |
DYNC1I1 | ZNF395 | ENSP00000320130 | ENSP00000340494 | Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kine [...] | Zinc finger protein 395; Plays a role in papillomavirus genes transcription. | 0.547 |
FAU | CUL7 | ENSP00000431822 | ENSP00000438788 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.992 |
FAU | MRPL2 | ENSP00000431822 | ENSP00000373404 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 0.992 |
FAU | RPL21 | ENSP00000431822 | ENSP00000346027 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | 0.999 |
FAU | RPL8 | ENSP00000431822 | ENSP00000262584 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 60S ribosomal protein L8; Component of the large ribosomal subunit. | 0.999 |
FAU | ZNF395 | ENSP00000431822 | ENSP00000340494 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Zinc finger protein 395; Plays a role in papillomavirus genes transcription. | 0.805 |
GTF3A | ZNF395 | ENSP00000370532 | ENSP00000340494 | Transcription factor IIIA; Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III- dependent transcription and may also maintain the transcription of other genes. Also binds the transcribed 5S RNA's (By similarity). | Zinc finger protein 395; Plays a role in papillomavirus genes transcription. | 0.565 |
LYRM4 | MRPL2 | ENSP00000443900 | ENSP00000373404 | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 0.400 |
LYRM4 | ZNF395 | ENSP00000443900 | ENSP00000340494 | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | Zinc finger protein 395; Plays a role in papillomavirus genes transcription. | 0.579 |
MRPL2 | CUL7 | ENSP00000373404 | ENSP00000438788 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.451 |
MRPL2 | FAU | ENSP00000373404 | ENSP00000431822 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.992 |
MRPL2 | LYRM4 | ENSP00000373404 | ENSP00000443900 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | 0.400 |
MRPL2 | RPL21 | ENSP00000373404 | ENSP00000346027 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | 0.964 |
MRPL2 | ZNF395 | ENSP00000373404 | ENSP00000340494 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | Zinc finger protein 395; Plays a role in papillomavirus genes transcription. | 0.548 |
RPL21 | CUL7 | ENSP00000346027 | ENSP00000438788 | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.973 |