node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BORCS8 | ZNF14 | ENSP00000425864 | ENSP00000340514 | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.408 |
C8orf48 | ZNF14 | ENSP00000297324 | ENSP00000340514 | Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48. | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.447 |
TRIM28 | ZNF14 | ENSP00000253024 | ENSP00000340514 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.676 |
TRIM28 | ZNF223 | ENSP00000253024 | ENSP00000401947 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 223; May be involved in transcriptional regulation. | 0.605 |
USP49 | ZNF14 | ENSP00000377797 | ENSP00000340514 | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family. | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.431 |
USP49 | ZNF223 | ENSP00000377797 | ENSP00000401947 | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family. | Zinc finger protein 223; May be involved in transcriptional regulation. | 0.641 |
ZNF14 | BORCS8 | ENSP00000340514 | ENSP00000425864 | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. | 0.408 |
ZNF14 | C8orf48 | ENSP00000340514 | ENSP00000297324 | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48. | 0.447 |
ZNF14 | TRIM28 | ENSP00000340514 | ENSP00000253024 | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.676 |
ZNF14 | USP49 | ENSP00000340514 | ENSP00000377797 | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family. | 0.431 |
ZNF14 | ZNF223 | ENSP00000340514 | ENSP00000401947 | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 223; May be involved in transcriptional regulation. | 0.408 |
ZNF223 | TRIM28 | ENSP00000401947 | ENSP00000253024 | Zinc finger protein 223; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.605 |
ZNF223 | USP49 | ENSP00000401947 | ENSP00000377797 | Zinc finger protein 223; May be involved in transcriptional regulation. | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family. | 0.641 |
ZNF223 | ZNF14 | ENSP00000401947 | ENSP00000340514 | Zinc finger protein 223; May be involved in transcriptional regulation. | Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.408 |