SYDE2 protein (human) - STRING interaction network

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SYDE2

Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (1194 aa)

Predicted Functional Partners:

RAC1

0.645

PPP4R3A

0.512

RASL11B

0.500

RHOF

0.484

ARRDC2

0.481

RAB3A

0.477

C1orf52

0.477

CHRM5

0.474

GCM1

0.471

CNTROB

0.465

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRDC2	RAB3A	ENSP00000222250	ENSP00000222256	Arrestin domain containing 2; Belongs to the arrestin family.	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	0.425
ARRDC2	RASL11B	ENSP00000222250	ENSP00000248706	Arrestin domain containing 2; Belongs to the arrestin family.	Ras-like protein family member 11B; RAS like family 11 member B.	0.449
ARRDC2	RHOF	ENSP00000222250	ENSP00000267205	Arrestin domain containing 2; Belongs to the arrestin family.	Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.	0.427
ARRDC2	SYDE2	ENSP00000222250	ENSP00000340594	Arrestin domain containing 2; Belongs to the arrestin family.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.481
C1orf52	SYDE2	ENSP00000419417	ENSP00000340594	UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.477
CHRM5	SYDE2	ENSP00000372750	ENSP00000340594	Muscarinic acetylcholine receptor M5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.474
CNTROB	SYDE2	ENSP00000369614	ENSP00000340594	Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.465
GCM1	SYDE2	ENSP00000259803	ENSP00000340594	Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.471
PPP4R3A	SYDE2	ENSP00000450864	ENSP00000340594	Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Belongs to the SMEK family.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.512
RAB3A	ARRDC2	ENSP00000222256	ENSP00000222250	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Arrestin domain containing 2; Belongs to the arrestin family.	0.425
RAB3A	SYDE2	ENSP00000222256	ENSP00000340594	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.477
RAC1	SYDE2	ENSP00000348461	ENSP00000340594	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.645
RASL11B	ARRDC2	ENSP00000248706	ENSP00000222250	Ras-like protein family member 11B; RAS like family 11 member B.	Arrestin domain containing 2; Belongs to the arrestin family.	0.449
RASL11B	RHOF	ENSP00000248706	ENSP00000267205	Ras-like protein family member 11B; RAS like family 11 member B.	Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.	0.442
RASL11B	SYDE2	ENSP00000248706	ENSP00000340594	Ras-like protein family member 11B; RAS like family 11 member B.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.500
RHOF	ARRDC2	ENSP00000267205	ENSP00000222250	Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.	Arrestin domain containing 2; Belongs to the arrestin family.	0.427
RHOF	RASL11B	ENSP00000267205	ENSP00000248706	Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.	Ras-like protein family member 11B; RAS like family 11 member B.	0.442
RHOF	SYDE2	ENSP00000267205	ENSP00000340594	Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	0.484
SYDE2	ARRDC2	ENSP00000340594	ENSP00000222250	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	Arrestin domain containing 2; Belongs to the arrestin family.	0.481
SYDE2	C1orf52	ENSP00000340594	ENSP00000419417	Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family.	0.477