node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP4 | AMBN | ENSP00000270593 | ENSP00000313809 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | 0.674 |
ACP4 | AMELX | ENSP00000270593 | ENSP00000370088 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. | 0.561 |
ACP4 | AMTN | ENSP00000270593 | ENSP00000341013 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. | 0.687 |
ACP4 | ENAM | ENSP00000270593 | ENSP00000379383 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.716 |
ACP4 | FAM20A | ENSP00000270593 | ENSP00000468308 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.596 |
ACP4 | KLK4 | ENSP00000270593 | ENSP00000326159 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). | 0.676 |
ACP4 | MMP20 | ENSP00000270593 | ENSP00000260228 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.532 |
ACP4 | ODAM | ENSP00000270593 | ENSP00000379401 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. | 0.535 |
ACP4 | ODAPH | ENSP00000270593 | ENSP00000406925 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite. | 0.620 |
AMBN | ACP4 | ENSP00000313809 | ENSP00000270593 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | 0.674 |
AMBN | AMELX | ENSP00000313809 | ENSP00000370088 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. | 0.984 |
AMBN | AMTN | ENSP00000313809 | ENSP00000341013 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. | 0.992 |
AMBN | ENAM | ENSP00000313809 | ENSP00000379383 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.999 |
AMBN | FAM20A | ENSP00000313809 | ENSP00000468308 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.825 |
AMBN | FAM20C | ENSP00000313809 | ENSP00000322323 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | 0.829 |
AMBN | KLK4 | ENSP00000313809 | ENSP00000326159 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). | 0.827 |
AMBN | MMP20 | ENSP00000313809 | ENSP00000260228 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.892 |
AMBN | ODAM | ENSP00000313809 | ENSP00000379401 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. | 0.781 |
AMBN | ODAPH | ENSP00000313809 | ENSP00000406925 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite. | 0.724 |
AMELX | ACP4 | ENSP00000370088 | ENSP00000270593 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis. | 0.561 |