node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
H1-1 | NOL12 | ENSP00000244573 | ENSP00000352021 | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). | Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family. | 0.503 |
H1-1 | PRR11 | ENSP00000244573 | ENSP00000262293 | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). | Proline-rich protein 11; Plays a critical role in cell cycle progression. | 0.564 |
H1-1 | ZNF189 | ENSP00000244573 | ENSP00000342019 | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.610 |
HMG20A | ZNF189 | ENSP00000371133 | ENSP00000342019 | High mobility group protein 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.450 |
LIG4 | ZNF189 | ENSP00000484288 | ENSP00000342019 | DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.442 |
MRPL50 | ZNF189 | ENSP00000363999 | ENSP00000342019 | Mitochondrial ribosomal protein L50. | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.677 |
NOL12 | H1-1 | ENSP00000352021 | ENSP00000244573 | Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family. | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). | 0.503 |
NOL12 | ZNF189 | ENSP00000352021 | ENSP00000342019 | Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family. | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.596 |
PRR11 | H1-1 | ENSP00000262293 | ENSP00000244573 | Proline-rich protein 11; Plays a critical role in cell cycle progression. | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). | 0.564 |
PRR11 | ZNF189 | ENSP00000262293 | ENSP00000342019 | Proline-rich protein 11; Plays a critical role in cell cycle progression. | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.422 |
TMEM186 | ZMAT5 | ENSP00000331640 | ENSP00000344241 | Transmembrane protein 186. | Zinc finger matrin-type 5. | 0.496 |
TMEM186 | ZNF189 | ENSP00000331640 | ENSP00000342019 | Transmembrane protein 186. | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.440 |
TRIM28 | ZNF189 | ENSP00000253024 | ENSP00000342019 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.518 |
TRIM28 | ZNF8 | ENSP00000253024 | ENSP00000477716 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 8; Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.418 |
ZMAT5 | TMEM186 | ENSP00000344241 | ENSP00000331640 | Zinc finger matrin-type 5. | Transmembrane protein 186. | 0.496 |
ZMAT5 | ZNF189 | ENSP00000344241 | ENSP00000342019 | Zinc finger matrin-type 5. | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.432 |
ZNF189 | H1-1 | ENSP00000342019 | ENSP00000244573 | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). | 0.610 |
ZNF189 | HMG20A | ENSP00000342019 | ENSP00000371133 | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | High mobility group protein 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). | 0.450 |
ZNF189 | LIG4 | ENSP00000342019 | ENSP00000484288 | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. | 0.442 |
ZNF189 | MRPL50 | ENSP00000342019 | ENSP00000363999 | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Mitochondrial ribosomal protein L50. | 0.677 |