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SIMC1 protein (human) - STRING interaction network
"SIMC1" - SUMO-interacting motif-containing protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIMC1SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 (457 aa)    
Predicted Functional Partners:
SPHKAP
A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1; A-kinase anchoring proteins (1700 aa)
           
  0.717
LRRN2
Leucine rich repeat neuronal 2; I-set domain containing (713 aa)
           
  0.717
SOBP
Sine oculis-binding protein homolog; Implicated in development of the cochlea (873 aa)
           
  0.644
OR2T34
Olfactory receptor 2T34; Odorant receptor; Olfactory receptors, family 2 (318 aa)
           
  0.543
TUFT1
Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family (390 aa)
           
  0.535
B4GALT7
Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family (327 aa)
           
  0.493
RNF111
E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase. Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and [...] (995 aa)
           
  0.451
TSTA3
GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Short chain dehydrogenase/reductase superfamily (321 aa)
           
  0.451
THG1L
Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (298 aa)
           
  0.447
ZNF354B
Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type (612 aa)
           
  0.442
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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