TMEM167B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	TMEM167B	ENSP00000220592	ENSP00000342148	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.471
AGO2	WDR47	ENSP00000220592	ENSP00000383599	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	WD repeat domain 47.	0.802
C1orf194	TMEM167B	ENSP00000358965	ENSP00000342148	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.413
FAM102B	FNDC7	ENSP00000359052	ENSP00000359034	Protein FAM102B; Family with sequence similarity 102 member B.	Fibronectin type III domain containing 7.	0.429
FAM102B	TMEM167B	ENSP00000359052	ENSP00000342148	Protein FAM102B; Family with sequence similarity 102 member B.	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.401
FNDC7	FAM102B	ENSP00000359034	ENSP00000359052	Fibronectin type III domain containing 7.	Protein FAM102B; Family with sequence similarity 102 member B.	0.429
FNDC7	TMEM167B	ENSP00000359034	ENSP00000342148	Fibronectin type III domain containing 7.	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.435
SF3B5	SNRPG	ENSP00000356541	ENSP00000393388	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.997
SF3B5	TMEM167B	ENSP00000356541	ENSP00000342148	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.416
SNRPG	SF3B5	ENSP00000393388	ENSP00000356541	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	0.997
SNRPG	TMEM167B	ENSP00000393388	ENSP00000342148	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.400
SNX14	TMEM167B	ENSP00000313121	ENSP00000342148	Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)).	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.422
TAF13	TMEM167B	ENSP00000355051	ENSP00000342148	Transcription initiation factor TFIID subunit 13; Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells. Belongs to the TAF13 family.	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.495
TAF13	WDR47	ENSP00000355051	ENSP00000383599	Transcription initiation factor TFIID subunit 13; Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells. Belongs to the TAF13 family.	WD repeat domain 47.	0.416
TMEM167B	AGO2	ENSP00000342148	ENSP00000220592	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.471
TMEM167B	C1orf194	ENSP00000342148	ENSP00000358965	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.	0.413
TMEM167B	FAM102B	ENSP00000342148	ENSP00000359052	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Protein FAM102B; Family with sequence similarity 102 member B.	0.401
TMEM167B	FNDC7	ENSP00000342148	ENSP00000359034	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Fibronectin type III domain containing 7.	0.435
TMEM167B	SF3B5	ENSP00000342148	ENSP00000356541	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	0.416
TMEM167B	SNRPG	ENSP00000342148	ENSP00000393388	Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.400