STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM221Transmembrane protein 221. (291 aa)    
Predicted Functional Partners:
GPR137C
Integral membrane protein GPR137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes; Belongs to the GPR137 family.
      
 0.629
TMEM132E
Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family.
      
 0.589
TMEM171
Transmembrane protein 171.
      
 0.572
TMEM211
Transmembrane protein 211.
      
 0.551
OVOL3
Putative transcription factor ovo-like protein 3; May act as a transcription regulator; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.519
GPR162
Probable G-protein coupled receptor 162; Orphan receptor.
      
 0.508
TMEM38A
Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
   
  
 0.500
TMEM150C
Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family.
      
 0.483
TMC5
Transmembrane channel-like protein 5; Probable ion channel.
    
 
 0.473
TMEM212
Transmembrane protein 212.
      
 0.470
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.