node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKS1A | FAM180A | ENSP00000353518 | ENSP00000342336 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Protein FAM180A; Family with sequence similarity 180 member A. | 0.514 |
ANKS1A | FANCE | ENSP00000353518 | ENSP00000229769 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. | 0.585 |
ANKS1A | GCC2 | ENSP00000353518 | ENSP00000307939 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.452 |
ANKS1A | KLHL35 | ENSP00000353518 | ENSP00000438526 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Kelch-like protein 35; Kelch like family member 35. | 0.516 |
ANKS1A | PI15 | ENSP00000353518 | ENSP00000260113 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.467 |
ANKS1A | SLC25A29 | ENSP00000353518 | ENSP00000352167 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.483 |
ANKS1A | TCP11 | ENSP00000353518 | ENSP00000501201 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization- promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. Belongs to the TCP11 family. | 0.629 |
C17orf67 | FAM180A | ENSP00000380959 | ENSP00000342336 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Protein FAM180A; Family with sequence similarity 180 member A. | 0.437 |
COL28A1 | FAM180A | ENSP00000382356 | ENSP00000342336 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | Protein FAM180A; Family with sequence similarity 180 member A. | 0.510 |
FAM180A | ANKS1A | ENSP00000342336 | ENSP00000353518 | Protein FAM180A; Family with sequence similarity 180 member A. | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | 0.514 |
FAM180A | C17orf67 | ENSP00000342336 | ENSP00000380959 | Protein FAM180A; Family with sequence similarity 180 member A. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.437 |
FAM180A | COL28A1 | ENSP00000342336 | ENSP00000382356 | Protein FAM180A; Family with sequence similarity 180 member A. | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. | 0.510 |
FAM180A | FANCE | ENSP00000342336 | ENSP00000229769 | Protein FAM180A; Family with sequence similarity 180 member A. | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. | 0.448 |
FAM180A | GCC2 | ENSP00000342336 | ENSP00000307939 | Protein FAM180A; Family with sequence similarity 180 member A. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.505 |
FAM180A | GLT6D1 | ENSP00000342336 | ENSP00000360829 | Protein FAM180A; Family with sequence similarity 180 member A. | Glycosyltransferase 6 domain containing 1; Belongs to the glycosyltransferase 6 family. | 0.479 |
FAM180A | KLHL35 | ENSP00000342336 | ENSP00000438526 | Protein FAM180A; Family with sequence similarity 180 member A. | Kelch-like protein 35; Kelch like family member 35. | 0.485 |
FAM180A | PI15 | ENSP00000342336 | ENSP00000260113 | Protein FAM180A; Family with sequence similarity 180 member A. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.566 |
FAM180A | SLC25A29 | ENSP00000342336 | ENSP00000352167 | Protein FAM180A; Family with sequence similarity 180 member A. | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.517 |
FAM180A | TCP11 | ENSP00000342336 | ENSP00000501201 | Protein FAM180A; Family with sequence similarity 180 member A. | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization- promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. Belongs to the TCP11 family. | 0.473 |
FANCE | ANKS1A | ENSP00000229769 | ENSP00000353518 | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). | 0.585 |