node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP9A | CD4 | ENSP00000342481 | ENSP00000011653 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.611 |
ATP9A | ITFG1 | ENSP00000342481 | ENSP00000319918 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Integrin alpha fg-gap repeat containing protein 1; T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity); Belongs to the TIP family | 0.636 |
ATP9A | MINOS1 | ENSP00000342481 | ENSP00000325562 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Mitochondrial contact site and cristae organizing system subunit 10; MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane | 0.639 |
ATP9A | MON2 | ENSP00000342481 | ENSP00000377250 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.750 |
ATP9A | NEO1 | ENSP00000342481 | ENSP00000341198 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | 0.619 |
ATP9A | NPLOC4 | ENSP00000342481 | ENSP00000331487 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Nuclear protein localization protein 4 homolog; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination [...] | 0.644 |
ATP9A | TMEM30A | ENSP00000342481 | ENSP00000230461 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] | 0.804 |
ATP9A | TMEM30B | ENSP00000342481 | ENSP00000450842 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...] | 0.695 |
ATP9A | TMEM30C | ENSP00000342481 | ENSP00000419663 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Cell cycle control protein 50C; Transmembrane protein 30C; Belongs to the CDC50/LEM3 family | 0.761 |
ATP9A | ZFP64 | ENSP00000342481 | ENSP00000216923 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | Zinc finger protein 64 homolog, isoforms 1 and 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.638 |
CD4 | ATP9A | ENSP00000011653 | ENSP00000342481 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | 0.611 |
ITFG1 | ATP9A | ENSP00000319918 | ENSP00000342481 | Integrin alpha fg-gap repeat containing protein 1; T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity); Belongs to the TIP family | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | 0.636 |
MINOS1 | ATP9A | ENSP00000325562 | ENSP00000342481 | Mitochondrial contact site and cristae organizing system subunit 10; MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | 0.639 |
MINOS1 | NPLOC4 | ENSP00000325562 | ENSP00000331487 | Mitochondrial contact site and cristae organizing system subunit 10; MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane | Nuclear protein localization protein 4 homolog; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination [...] | 0.650 |
MON2 | ATP9A | ENSP00000377250 | ENSP00000342481 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | 0.750 |
MON2 | NEO1 | ENSP00000377250 | ENSP00000341198 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | 0.596 |
MON2 | TMEM30A | ENSP00000377250 | ENSP00000230461 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] | 0.433 |
MON2 | TMEM30B | ENSP00000377250 | ENSP00000450842 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...] | 0.400 |
MON2 | TMEM30C | ENSP00000377250 | ENSP00000419663 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Cell cycle control protein 50C; Transmembrane protein 30C; Belongs to the CDC50/LEM3 family | 0.427 |
NEO1 | ATP9A | ENSP00000341198 | ENSP00000342481 | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A | 0.619 |