node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD300A | CD300C | ENSP00000353259 | ENSP00000329507 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | 0.719 |
CD300A | CD300E | ENSP00000353259 | ENSP00000376395 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 2; Probably acts as an activating receptor. | 0.646 |
CD300A | CD300LB | ENSP00000353259 | ENSP00000376397 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. | 0.821 |
CD300A | CD300LD | ENSP00000353259 | ENSP00000364501 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 5; CD300 molecule like family member d. | 0.629 |
CD300A | CD300LF | ENSP00000353259 | ENSP00000462309 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 1; Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to cer [...] | 0.762 |
CD300A | TREM1 | ENSP00000353259 | ENSP00000244709 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. | 0.657 |
CD300A | TREM2 | ENSP00000353259 | ENSP00000362205 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein pa [...] | 0.569 |
CD300A | TREML1 | ENSP00000353259 | ENSP00000402855 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. | 0.518 |
CD300A | TREML2 | ENSP00000353259 | ENSP00000418767 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. | 0.453 |
CD300A | TREML4 | ENSP00000353259 | ENSP00000342570 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages. | 0.484 |
CD300C | CD300A | ENSP00000329507 | ENSP00000353259 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | 0.719 |
CD300C | CD300E | ENSP00000329507 | ENSP00000376395 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 2; Probably acts as an activating receptor. | 0.639 |
CD300C | CD300LB | ENSP00000329507 | ENSP00000376397 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. | 0.939 |
CD300C | CD300LD | ENSP00000329507 | ENSP00000364501 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 5; CD300 molecule like family member d. | 0.446 |
CD300C | CD300LF | ENSP00000329507 | ENSP00000462309 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 1; Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to cer [...] | 0.815 |
CD300C | TREM1 | ENSP00000329507 | ENSP00000244709 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. | 0.620 |
CD300C | TREM2 | ENSP00000329507 | ENSP00000362205 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein pa [...] | 0.503 |
CD300C | TREML1 | ENSP00000329507 | ENSP00000402855 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. | 0.483 |
CD300C | TREML2 | ENSP00000329507 | ENSP00000418767 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. | 0.441 |
CD300C | TREML4 | ENSP00000329507 | ENSP00000342570 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages. | 0.498 |