node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKBH6 | FAM184A | ENSP00000368152 | ENSP00000342604 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family | Protein FAM184A; Family with sequence similarity 184 member A | 0.751 |
ALKBH6 | GAPVD1 | ENSP00000368152 | ENSP00000377664 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.594 |
ANAPC7 | CEP95 | ENSP00000394394 | ENSP00000450461 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains; Belongs to the APC7 family | Centrosomal protein of 95 kda; Centrosomal protein 95 | 0.513 |
ANAPC7 | FAM184A | ENSP00000394394 | ENSP00000342604 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains; Belongs to the APC7 family | Protein FAM184A; Family with sequence similarity 184 member A | 0.513 |
CAMTA2 | FAM184A | ENSP00000412886 | ENSP00000342604 | Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor; Belongs to the CAMTA family | Protein FAM184A; Family with sequence similarity 184 member A | 0.505 |
CEP250 | FAM184A | ENSP00000380661 | ENSP00000342604 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Protein FAM184A; Family with sequence similarity 184 member A | 0.422 |
CEP95 | ANAPC7 | ENSP00000450461 | ENSP00000394394 | Centrosomal protein of 95 kda; Centrosomal protein 95 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains; Belongs to the APC7 family | 0.513 |
CEP95 | FAM184A | ENSP00000450461 | ENSP00000342604 | Centrosomal protein of 95 kda; Centrosomal protein 95 | Protein FAM184A; Family with sequence similarity 184 member A | 0.572 |
FAM184A | ALKBH6 | ENSP00000342604 | ENSP00000368152 | Protein FAM184A; Family with sequence similarity 184 member A | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family | 0.751 |
FAM184A | ANAPC7 | ENSP00000342604 | ENSP00000394394 | Protein FAM184A; Family with sequence similarity 184 member A | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains; Belongs to the APC7 family | 0.513 |
FAM184A | CAMTA2 | ENSP00000342604 | ENSP00000412886 | Protein FAM184A; Family with sequence similarity 184 member A | Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor; Belongs to the CAMTA family | 0.505 |
FAM184A | CEP250 | ENSP00000342604 | ENSP00000380661 | Protein FAM184A; Family with sequence similarity 184 member A | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | 0.422 |
FAM184A | CEP95 | ENSP00000342604 | ENSP00000450461 | Protein FAM184A; Family with sequence similarity 184 member A | Centrosomal protein of 95 kda; Centrosomal protein 95 | 0.572 |
FAM184A | FOXB2 | ENSP00000342604 | ENSP00000365898 | Protein FAM184A; Family with sequence similarity 184 member A | Forkhead box protein B2; Transcription factor; Forkhead boxes | 0.541 |
FAM184A | GAPVD1 | ENSP00000342604 | ENSP00000377664 | Protein FAM184A; Family with sequence similarity 184 member A | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.728 |
FAM184A | KIAA1244 | ENSP00000342604 | ENSP00000251691 | Protein FAM184A; Family with sequence similarity 184 member A | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells | 0.459 |
FAM184A | KIAA1644 | ENSP00000342604 | ENSP00000370568 | Protein FAM184A; Family with sequence similarity 184 member A | Uncharacterized protein KIAA1644; KIAA1644 | 0.468 |
FAM184A | USO1 | ENSP00000342604 | ENSP00000444850 | Protein FAM184A; Family with sequence similarity 184 member A | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Armadillo-like helical domain containing | 0.490 |
FOXB2 | FAM184A | ENSP00000365898 | ENSP00000342604 | Forkhead box protein B2; Transcription factor; Forkhead boxes | Protein FAM184A; Family with sequence similarity 184 member A | 0.541 |
GAPVD1 | ALKBH6 | ENSP00000377664 | ENSP00000368152 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family | 0.594 |