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POU1F1 protein (human) - STRING interaction network
"POU1F1" - Pituitary-specific positive transcription factor 1 in Homo sapiens
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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POU1F1Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5’-TAAAT-3’. Activates growth hormone and prolactin genes; Belongs to the POU transcription factor family. Class- 1 subfamily (317 aa)    
Predicted Functional Partners:
PROP1
Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes; PRD class homeoboxes and pseudogenes (226 aa)
     
 
  0.924
LHX4
LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes (390 aa)
     
 
  0.900
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands (138 aa)
     
   
  0.889
LHX3
LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1; LIM class homeoboxes (402 aa)
     
 
  0.885
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family (227 aa)
     
   
  0.852
HESX1
Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5’-AGCTTGAGTCTAATTGAATTAACTGTAC-3’. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation; Belongs to the ANF homeobox family (185 aa)
     
 
  0.851
GHRHR
Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family (423 aa)
     
   
  0.848
TBX19
T-box transcription factor TBX19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters; T-boxes (448 aa)
     
 
  0.847
CGA
Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family (147 aa)
     
   
  0.817
ESX1
Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover; PRD class homeoboxes and pseudogenes (406 aa)
     
 
  0.804
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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