PRR27 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C4orf36	FDCSP	ENSP00000295898	ENSP00000318437	Uncharacterized protein C4orf36; Chromosome 4 open reading frame 36.	Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	0.465
C4orf36	PRR27	ENSP00000295898	ENSP00000343172	Uncharacterized protein C4orf36; Chromosome 4 open reading frame 36.	Proline-rich protein 27; Proline rich 27.	0.683
CABS1	PRR27	ENSP00000273936	ENSP00000343172	Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1.	Proline-rich protein 27; Proline rich 27.	0.465
CST5	HTN1	ENSP00000307132	ENSP00000424501	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	His1-(31-57)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities; Belongs to the histatin/statherin family.	0.623
CST5	PRR27	ENSP00000307132	ENSP00000343172	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Proline-rich protein 27; Proline rich 27.	0.675
CST5	STATH	ENSP00000307132	ENSP00000246895	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	0.445
FDCSP	C4orf36	ENSP00000318437	ENSP00000295898	Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	Uncharacterized protein C4orf36; Chromosome 4 open reading frame 36.	0.465
FDCSP	ODAM	ENSP00000318437	ENSP00000379401	Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family.	0.715
FDCSP	PRR27	ENSP00000318437	ENSP00000343172	Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	Proline-rich protein 27; Proline rich 27.	0.591
FDCSP	STATH	ENSP00000318437	ENSP00000246895	Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	0.441
HTN1	CST5	ENSP00000424501	ENSP00000307132	His1-(31-57)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities; Belongs to the histatin/statherin family.	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	0.623
HTN1	PRR27	ENSP00000424501	ENSP00000343172	His1-(31-57)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities; Belongs to the histatin/statherin family.	Proline-rich protein 27; Proline rich 27.	0.744
HTN1	STATH	ENSP00000424501	ENSP00000246895	His1-(31-57)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities; Belongs to the histatin/statherin family.	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	0.988
HTN1	ZG16B	ENSP00000424501	ENSP00000371715	His1-(31-57)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities; Belongs to the histatin/statherin family.	Zymogen granule protein 16B; Belongs to the jacalin lectin family.	0.414
ODAM	FDCSP	ENSP00000379401	ENSP00000318437	Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family.	Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	0.715
ODAM	PRR27	ENSP00000379401	ENSP00000343172	Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family.	Proline-rich protein 27; Proline rich 27.	0.563
PRR27	C4orf36	ENSP00000343172	ENSP00000295898	Proline-rich protein 27; Proline rich 27.	Uncharacterized protein C4orf36; Chromosome 4 open reading frame 36.	0.683
PRR27	CABS1	ENSP00000343172	ENSP00000273936	Proline-rich protein 27; Proline rich 27.	Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1.	0.465
PRR27	CST5	ENSP00000343172	ENSP00000307132	Proline-rich protein 27; Proline rich 27.	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	0.675
PRR27	FDCSP	ENSP00000343172	ENSP00000318437	Proline-rich protein 27; Proline rich 27.	Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	0.591