node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C7orf57 | FAM222A | ENSP00000335500 | ENSP00000443292 | Uncharacterized protein C7orf57; Chromosome 7 open reading frame 57. | Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family. | 0.460 |
C7orf57 | PPP1R32 | ENSP00000335500 | ENSP00000344140 | Uncharacterized protein C7orf57; Chromosome 7 open reading frame 57. | Protein phosphatase 1 regulatory subunit 32. | 0.582 |
CCDC181 | PPP1R32 | ENSP00000356780 | ENSP00000344140 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | Protein phosphatase 1 regulatory subunit 32. | 0.574 |
CLDND2 | PPP1R32 | ENSP00000291715 | ENSP00000344140 | Claudin domain containing 2. | Protein phosphatase 1 regulatory subunit 32. | 0.434 |
DUSP15 | MYRF | ENSP00000278979 | ENSP00000278836 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | 0.542 |
DUSP15 | PPP1R32 | ENSP00000278979 | ENSP00000344140 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Protein phosphatase 1 regulatory subunit 32. | 0.429 |
FAM222A | C7orf57 | ENSP00000443292 | ENSP00000335500 | Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family. | Uncharacterized protein C7orf57; Chromosome 7 open reading frame 57. | 0.460 |
FAM222A | PPP1R32 | ENSP00000443292 | ENSP00000344140 | Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family. | Protein phosphatase 1 regulatory subunit 32. | 0.455 |
MYRF | DUSP15 | ENSP00000278836 | ENSP00000278979 | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.542 |
MYRF | PPP1R32 | ENSP00000278836 | ENSP00000344140 | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | Protein phosphatase 1 regulatory subunit 32. | 0.434 |
PPP1CA | PPP1R32 | ENSP00000326031 | ENSP00000344140 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | Protein phosphatase 1 regulatory subunit 32. | 0.425 |
PPP1R32 | C7orf57 | ENSP00000344140 | ENSP00000335500 | Protein phosphatase 1 regulatory subunit 32. | Uncharacterized protein C7orf57; Chromosome 7 open reading frame 57. | 0.582 |
PPP1R32 | CCDC181 | ENSP00000344140 | ENSP00000356780 | Protein phosphatase 1 regulatory subunit 32. | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | 0.574 |
PPP1R32 | CLDND2 | ENSP00000344140 | ENSP00000291715 | Protein phosphatase 1 regulatory subunit 32. | Claudin domain containing 2. | 0.434 |
PPP1R32 | DUSP15 | ENSP00000344140 | ENSP00000278979 | Protein phosphatase 1 regulatory subunit 32. | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.429 |
PPP1R32 | FAM222A | ENSP00000344140 | ENSP00000443292 | Protein phosphatase 1 regulatory subunit 32. | Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family. | 0.455 |
PPP1R32 | MYRF | ENSP00000344140 | ENSP00000278836 | Protein phosphatase 1 regulatory subunit 32. | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | 0.434 |
PPP1R32 | PPP1CA | ENSP00000344140 | ENSP00000326031 | Protein phosphatase 1 regulatory subunit 32. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.425 |
PPP1R32 | SDHA | ENSP00000344140 | ENSP00000264932 | Protein phosphatase 1 regulatory subunit 32. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor ; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.820 |
PPP1R32 | SDHAF2 | ENSP00000344140 | ENSP00000301761 | Protein phosphatase 1 regulatory subunit 32. | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. | 0.442 |