node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTSB | CTSD | ENSP00000345672 | ENSP00000236671 | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. | 0.977 |
CTSB | IFITM10 | ENSP00000345672 | ENSP00000344430 | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. | Interferon induced transmembrane protein 10. | 0.555 |
CTSD | CTSB | ENSP00000236671 | ENSP00000345672 | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. | 0.977 |
CTSD | IFITM10 | ENSP00000236671 | ENSP00000344430 | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. | Interferon induced transmembrane protein 10. | 0.404 |
IFITM10 | CTSB | ENSP00000344430 | ENSP00000345672 | Interferon induced transmembrane protein 10. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. | 0.555 |
IFITM10 | CTSD | ENSP00000344430 | ENSP00000236671 | Interferon induced transmembrane protein 10. | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. | 0.404 |
IFITM10 | IFITM5 | ENSP00000344430 | ENSP00000372059 | Interferon induced transmembrane protein 10. | Interferon-induced transmembrane protein 5; Required for normal bone mineralization. Belongs to the CD225/Dispanin family. | 0.466 |
IFITM10 | KRTAP5-1 | ENSP00000344430 | ENSP00000371606 | Interferon induced transmembrane protein 10. | Keratin-associated protein 5-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.454 |
IFITM10 | PGGHG | ENSP00000344430 | ENSP00000387185 | Interferon induced transmembrane protein 10. | Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. | 0.531 |
IFITM10 | PRRT1B | ENSP00000344430 | ENSP00000490857 | Interferon induced transmembrane protein 10. | Proline rich transmembrane protein 1B. | 0.418 |
IFITM10 | SCNN1A | ENSP00000344430 | ENSP00000353292 | Interferon induced transmembrane protein 10. | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. | 0.406 |
IFITM5 | IFITM10 | ENSP00000372059 | ENSP00000344430 | Interferon-induced transmembrane protein 5; Required for normal bone mineralization. Belongs to the CD225/Dispanin family. | Interferon induced transmembrane protein 10. | 0.466 |
IFITM5 | PGGHG | ENSP00000372059 | ENSP00000387185 | Interferon-induced transmembrane protein 5; Required for normal bone mineralization. Belongs to the CD225/Dispanin family. | Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. | 0.627 |
KRTAP5-1 | IFITM10 | ENSP00000371606 | ENSP00000344430 | Keratin-associated protein 5-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | Interferon induced transmembrane protein 10. | 0.454 |
PGGHG | IFITM10 | ENSP00000387185 | ENSP00000344430 | Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. | Interferon induced transmembrane protein 10. | 0.531 |
PGGHG | IFITM5 | ENSP00000387185 | ENSP00000372059 | Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. | Interferon-induced transmembrane protein 5; Required for normal bone mineralization. Belongs to the CD225/Dispanin family. | 0.627 |
PRRT1B | IFITM10 | ENSP00000490857 | ENSP00000344430 | Proline rich transmembrane protein 1B. | Interferon induced transmembrane protein 10. | 0.418 |
SCNN1A | IFITM10 | ENSP00000353292 | ENSP00000344430 | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. | Interferon induced transmembrane protein 10. | 0.406 |