APOL3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOL1	APOL3	ENSP00000317674	ENSP00000344577	Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.552
APOL1	APOL6	ENSP00000317674	ENSP00000386280	Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.532
APOL1	GBP1	ENSP00000317674	ENSP00000359504	Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	0.406
APOL3	APOL1	ENSP00000344577	ENSP00000317674	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	0.552
APOL3	APOL6	ENSP00000344577	ENSP00000386280	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.424
APOL3	GBP1	ENSP00000344577	ENSP00000359504	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	0.535
APOL3	GBP4	ENSP00000344577	ENSP00000359490	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	0.501
APOL3	LDHA	ENSP00000344577	ENSP00000445175	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family.	0.578
APOL6	APOL1	ENSP00000386280	ENSP00000317674	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	0.532
APOL6	APOL3	ENSP00000386280	ENSP00000344577	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.424
APOL6	GBP1	ENSP00000386280	ENSP00000359504	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	0.519
APOL6	GBP4	ENSP00000386280	ENSP00000359490	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	0.503
GBP1	APOL1	ENSP00000359504	ENSP00000317674	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	0.406
GBP1	APOL3	ENSP00000359504	ENSP00000344577	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.535
GBP1	APOL6	ENSP00000359504	ENSP00000386280	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.519
GBP1	GBP4	ENSP00000359504	ENSP00000359490	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	0.954
GBP4	APOL3	ENSP00000359490	ENSP00000344577	Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.501
GBP4	APOL6	ENSP00000359490	ENSP00000386280	Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.503
GBP4	GBP1	ENSP00000359490	ENSP00000359504	Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	0.954
LDHA	APOL3	ENSP00000445175	ENSP00000344577	Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family.	Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	0.578