node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C19orf67 | PALM3 | ENSP00000449137 | ENSP00000344996 | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.476 |
CD69 | PALM3 | ENSP00000228434 | ENSP00000344996 | Early activation antigen CD69; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.489 |
COBL | PALM3 | ENSP00000378912 | ENSP00000344996 | Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.475 |
COBL | POU6F2 | ENSP00000378912 | ENSP00000384004 | Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. | POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. | 0.402 |
CSMD3 | PALM3 | ENSP00000297405 | ENSP00000344996 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.439 |
FPGS | PALM3 | ENSP00000362344 | ENSP00000344996 | Folylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.426 |
IFIT1B | PALM3 | ENSP00000360874 | ENSP00000344996 | Interferon induced protein with tetratricopeptide repeats 1B. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.455 |
PALM3 | C19orf67 | ENSP00000344996 | ENSP00000449137 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family. | 0.476 |
PALM3 | CD69 | ENSP00000344996 | ENSP00000228434 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | Early activation antigen CD69; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. | 0.489 |
PALM3 | COBL | ENSP00000344996 | ENSP00000378912 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. | 0.475 |
PALM3 | CSMD3 | ENSP00000344996 | ENSP00000297405 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.439 |
PALM3 | FPGS | ENSP00000344996 | ENSP00000362344 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | Folylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. | 0.426 |
PALM3 | IFIT1B | ENSP00000344996 | ENSP00000360874 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | Interferon induced protein with tetratricopeptide repeats 1B. | 0.455 |
PALM3 | POU6F2 | ENSP00000344996 | ENSP00000384004 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. | 0.446 |
PALM3 | SIGIRR | ENSP00000344996 | ENSP00000403104 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. | 0.679 |
PALM3 | THSD4 | ENSP00000344996 | ENSP00000347484 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). | 0.451 |
PALM3 | TSSC4 | ENSP00000344996 | ENSP00000331087 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | Protein TSSC4; Tumor suppressing subtransferable candidate 4. | 0.470 |
POU6F2 | COBL | ENSP00000384004 | ENSP00000378912 | POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. | Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. | 0.402 |
POU6F2 | PALM3 | ENSP00000384004 | ENSP00000344996 | POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.446 |
SIGIRR | PALM3 | ENSP00000403104 | ENSP00000344996 | Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling. | 0.679 |