GLI4 protein (human) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

GLI4

GLI family zinc finger 4; Zinc fingers C2H2-type (376 aa)

Predicted Functional Partners:

LRRC14

0.596

KIAA1875

0.503

NRAS

0.499

MYCL

0.483

LRRC24

0.464

STK36

0.451

PCDHGA2

0.429

C1orf35

0.426

MYCN

0.410

PTCH2

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf35	GLI4	ENSP00000272139	ENSP00000345024	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35	GLI family zinc finger 4; Zinc fingers C2H2-type	0.426
C1orf35	LRRC14	ENSP00000272139	ENSP00000292524	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily	0.476
C1orf35	LRRC24	ENSP00000272139	ENSP00000434849	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24; I-set domain containing	0.478
GLI4	C1orf35	ENSP00000345024	ENSP00000272139	GLI family zinc finger 4; Zinc fingers C2H2-type	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35	0.426
GLI4	KIAA1875	ENSP00000345024	ENSP00000320648	GLI family zinc finger 4; Zinc fingers C2H2-type	WD repeat-containing protein 97; KIAA1875	0.503
GLI4	LRRC14	ENSP00000345024	ENSP00000292524	GLI family zinc finger 4; Zinc fingers C2H2-type	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily	0.596
GLI4	LRRC24	ENSP00000345024	ENSP00000434849	GLI family zinc finger 4; Zinc fingers C2H2-type	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24; I-set domain containing	0.464
GLI4	MYCL	ENSP00000345024	ENSP00000380494	GLI family zinc finger 4; Zinc fingers C2H2-type	Protein L-Myc; MYCL proto-oncogene, bHLH transcription factor; Basic helix-loop-helix proteins	0.483
GLI4	MYCN	ENSP00000345024	ENSP00000281043	GLI family zinc finger 4; Zinc fingers C2H2-type	N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells; Basic helix-loop-helix proteins	0.410
GLI4	NRAS	ENSP00000345024	ENSP00000358548	GLI family zinc finger 4; Zinc fingers C2H2-type	Nras proto-oncogene, gtpase; GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity	0.499
GLI4	PCDHGA2	ENSP00000345024	ENSP00000378077	GLI family zinc finger 4; Zinc fingers C2H2-type	Protocadherin gamma-A2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins	0.429
GLI4	PTCH2	ENSP00000345024	ENSP00000361266	GLI family zinc finger 4; Zinc fingers C2H2-type	Protein patched homolog 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH)	0.410
GLI4	STK36	ENSP00000345024	ENSP00000295709	GLI family zinc finger 4; Zinc fingers C2H2-type	Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...]	0.451
KIAA1875	GLI4	ENSP00000320648	ENSP00000345024	WD repeat-containing protein 97; KIAA1875	GLI family zinc finger 4; Zinc fingers C2H2-type	0.503
KIAA1875	LRRC14	ENSP00000320648	ENSP00000292524	WD repeat-containing protein 97; KIAA1875	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily	0.519
KIAA1875	LRRC24	ENSP00000320648	ENSP00000434849	WD repeat-containing protein 97; KIAA1875	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24; I-set domain containing	0.544
LRRC14	C1orf35	ENSP00000292524	ENSP00000272139	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35	0.476
LRRC14	GLI4	ENSP00000292524	ENSP00000345024	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily	GLI family zinc finger 4; Zinc fingers C2H2-type	0.596
LRRC14	KIAA1875	ENSP00000292524	ENSP00000320648	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily	WD repeat-containing protein 97; KIAA1875	0.519
LRRC14	LRRC24	ENSP00000292524	ENSP00000434849	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24; I-set domain containing	0.617