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NKX2-4 protein (human) - STRING interaction network
"NKX2-4" - Homeobox protein Nkx-2.4 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NKX2-4Homeobox protein Nkx-2.4; Probable transcription factor; NKL subclass homeoboxes and pseudogenes (354 aa)    
Predicted Functional Partners:
DCUN1D1
DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also [...] (259 aa)
           
  0.904
TBR1
T-box brain protein 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development; T-boxes (682 aa)
       
 
  0.515
TBX4
T-box transcription factor TBX4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation; T-boxes (545 aa)
       
 
  0.509
ZNF202
Zinc finger protein 202; Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease; SCAN domain containing (648 aa)
       
 
  0.502
LHX6
LIM/homeobox protein Lhx6; Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity); LIM class homeoboxes (392 aa)
     
 
  0.495
FOXB2
Forkhead box protein B2; Transcription factor; Forkhead boxes (432 aa)
     
 
  0.481
TBX5
T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter; T-boxes (518 aa)
       
 
  0.470
EVA1B
Eva-1 homolog B; Belongs to the EVA1 family (165 aa)
           
  0.441
GSX2
GS homeobox 2; During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5’-CNAATTAG-3’ DNA sequence; HOXL subclass homeoboxes (304 aa)
     
 
0.435
STK31
Serine/threonine kinase 31; Tudor domain containing (1019 aa)
           
  0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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