node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C8orf74 | KIZ | ENSP00000307129 | ENSP00000479542 | Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74. | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family. | 0.472 |
C8orf74 | NKX2-4 | ENSP00000307129 | ENSP00000345147 | Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74. | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | 0.549 |
DCUN1D1 | NKX2-4 | ENSP00000292782 | ENSP00000345147 | DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also [...] | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | 0.900 |
FOXB2 | NKX2-4 | ENSP00000365898 | ENSP00000345147 | Forkhead box protein B2; Transcription factor. | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | 0.409 |
KIZ | C8orf74 | ENSP00000479542 | ENSP00000307129 | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family. | Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74. | 0.472 |
KIZ | NKX2-4 | ENSP00000479542 | ENSP00000345147 | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family. | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | 0.507 |
KIZ | XRN2 | ENSP00000479542 | ENSP00000366396 | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family. | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | 0.420 |
NKX2-2 | NKX2-4 | ENSP00000366347 | ENSP00000345147 | Homeobox protein Nkx-2.2; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family. | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | 0.436 |
NKX2-4 | C8orf74 | ENSP00000345147 | ENSP00000307129 | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74. | 0.549 |
NKX2-4 | DCUN1D1 | ENSP00000345147 | ENSP00000292782 | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also [...] | 0.900 |
NKX2-4 | FOXB2 | ENSP00000345147 | ENSP00000365898 | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | Forkhead box protein B2; Transcription factor. | 0.409 |
NKX2-4 | KIZ | ENSP00000345147 | ENSP00000479542 | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family. | 0.507 |
NKX2-4 | NKX2-2 | ENSP00000345147 | ENSP00000366347 | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | Homeobox protein Nkx-2.2; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family. | 0.436 |
NKX2-4 | XRN2 | ENSP00000345147 | ENSP00000366396 | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | 0.445 |
XRN2 | KIZ | ENSP00000366396 | ENSP00000479542 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family. | 0.420 |
XRN2 | NKX2-4 | ENSP00000366396 | ENSP00000345147 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family. | 0.445 |