node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNG1 | NDRG3 | ENSP00000344635 | ENSP00000345292 | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.547 |
CSTF1 | NDRG3 | ENSP00000217109 | ENSP00000345292 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.486 |
EGLN1 | NDRG3 | ENSP00000355601 | ENSP00000345292 | Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is [...] | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.558 |
FXYD1 | NDRG3 | ENSP00000481244 | ENSP00000345292 | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.447 |
HDHD3 | NDRG3 | ENSP00000238379 | ENSP00000345292 | Haloacid dehalogenase like hydrolase domain containing 3. | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.478 |
MYCN | NDRG3 | ENSP00000281043 | ENSP00000345292 | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.798 |
MYCN | STK38L | ENSP00000281043 | ENSP00000373684 | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.418 |
NDRG3 | CCNG1 | ENSP00000345292 | ENSP00000344635 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). | 0.547 |
NDRG3 | CSTF1 | ENSP00000345292 | ENSP00000217109 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | 0.486 |
NDRG3 | EGLN1 | ENSP00000345292 | ENSP00000355601 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is [...] | 0.558 |
NDRG3 | FXYD1 | ENSP00000345292 | ENSP00000481244 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. | 0.447 |
NDRG3 | HDHD3 | ENSP00000345292 | ENSP00000238379 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | Haloacid dehalogenase like hydrolase domain containing 3. | 0.478 |
NDRG3 | MYCN | ENSP00000345292 | ENSP00000281043 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | 0.798 |
NDRG3 | NOCT | ENSP00000345292 | ENSP00000280614 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | Nocturnin; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role [...] | 0.444 |
NDRG3 | RAF1 | ENSP00000345292 | ENSP00000401888 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.644 |
NDRG3 | STK38L | ENSP00000345292 | ENSP00000373684 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.922 |
NDRG3 | TARDBP | ENSP00000345292 | ENSP00000240185 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | TAR DNA-binding protein 43; RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondria [...] | 0.479 |
NOCT | NDRG3 | ENSP00000280614 | ENSP00000345292 | Nocturnin; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role [...] | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.444 |
RAF1 | NDRG3 | ENSP00000401888 | ENSP00000345292 | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family. | 0.644 |
STK38L | MYCN | ENSP00000373684 | ENSP00000281043 | Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | 0.418 |