SH2D4B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DYDC1	DYDC2	ENSP00000361278	ENSP00000361272	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	DPY30 domain containing 2; Belongs to the dpy-30 family.	0.582
DYDC1	SH2D4B	ENSP00000361278	ENSP00000345295	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	SH2 domain containing 4B.	0.697
DYDC1	TMEM254	ENSP00000361278	ENSP00000361355	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	Transmembrane protein 254.	0.503
DYDC1	TSPAN14	ENSP00000361278	ENSP00000361231	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).	0.621
DYDC2	DYDC1	ENSP00000361272	ENSP00000361278	DPY30 domain containing 2; Belongs to the dpy-30 family.	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	0.582
DYDC2	SH2D4B	ENSP00000361272	ENSP00000345295	DPY30 domain containing 2; Belongs to the dpy-30 family.	SH2 domain containing 4B.	0.657
DYDC2	TMEM254	ENSP00000361272	ENSP00000361355	DPY30 domain containing 2; Belongs to the dpy-30 family.	Transmembrane protein 254.	0.462
DYDC2	TSPAN14	ENSP00000361272	ENSP00000361231	DPY30 domain containing 2; Belongs to the dpy-30 family.	Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).	0.595
FBXO39	LONP2	ENSP00000321386	ENSP00000285737	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.	0.430
FBXO39	SH2D4B	ENSP00000321386	ENSP00000345295	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	SH2 domain containing 4B.	0.537
FBXO39	UBOX5	ENSP00000321386	ENSP00000217173	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.	0.491
LONP2	FBXO39	ENSP00000285737	ENSP00000321386	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	0.430
LONP2	SH2D4B	ENSP00000285737	ENSP00000345295	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.	SH2 domain containing 4B.	0.465
PALM2AKAP2	SH2D4B	ENSP00000363654	ENSP00000345295	A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).	SH2 domain containing 4B.	0.469
POLR3A	SH2D4B	ENSP00000361446	ENSP00000345295	DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single- stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to pro [...]	SH2 domain containing 4B.	0.514
SH2D4B	DYDC1	ENSP00000345295	ENSP00000361278	SH2 domain containing 4B.	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	0.697
SH2D4B	DYDC2	ENSP00000345295	ENSP00000361272	SH2 domain containing 4B.	DPY30 domain containing 2; Belongs to the dpy-30 family.	0.657
SH2D4B	FBXO39	ENSP00000345295	ENSP00000321386	SH2 domain containing 4B.	F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	0.537
SH2D4B	LONP2	ENSP00000345295	ENSP00000285737	SH2 domain containing 4B.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.	0.465
SH2D4B	PALM2AKAP2	ENSP00000345295	ENSP00000363654	SH2 domain containing 4B.	A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).	0.469