node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DYDC1 | DYDC2 | ENSP00000361278 | ENSP00000361272 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | DPY30 domain containing 2; Belongs to the dpy-30 family. | 0.712 |
DYDC1 | SH2D4B | ENSP00000361278 | ENSP00000345295 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | SH2 domain containing 4B. | 0.686 |
DYDC1 | TMEM254 | ENSP00000361278 | ENSP00000361355 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Transmembrane protein 254. | 0.467 |
DYDC1 | TSPAN14 | ENSP00000361278 | ENSP00000361231 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). | 0.643 |
DYDC2 | DYDC1 | ENSP00000361272 | ENSP00000361278 | DPY30 domain containing 2; Belongs to the dpy-30 family. | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.712 |
DYDC2 | SH2D4B | ENSP00000361272 | ENSP00000345295 | DPY30 domain containing 2; Belongs to the dpy-30 family. | SH2 domain containing 4B. | 0.646 |
DYDC2 | TMEM254 | ENSP00000361272 | ENSP00000361355 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Transmembrane protein 254. | 0.429 |
DYDC2 | TSPAN14 | ENSP00000361272 | ENSP00000361231 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). | 0.611 |
EFCC1 | SH2D4B | ENSP00000414597 | ENSP00000345295 | EF-hand and coiled-coil domain containing 1. | SH2 domain containing 4B. | 0.418 |
FBXO39 | LONP2 | ENSP00000321386 | ENSP00000285737 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. | 0.410 |
FBXO39 | SH2D4B | ENSP00000321386 | ENSP00000345295 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | SH2 domain containing 4B. | 0.543 |
FBXO39 | UBOX5 | ENSP00000321386 | ENSP00000217173 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.508 |
LONP2 | FBXO39 | ENSP00000285737 | ENSP00000321386 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.410 |
LONP2 | RANGRF | ENSP00000285737 | ENSP00000226105 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. | Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Belongs to the MOG1 family. | 0.402 |
LONP2 | SH2D4B | ENSP00000285737 | ENSP00000345295 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. | SH2 domain containing 4B. | 0.477 |
LONP2 | SHQ1 | ENSP00000285737 | ENSP00000315182 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. | Protein SHQ1 homolog; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. | 0.410 |
LONP2 | UBOX5 | ENSP00000285737 | ENSP00000217173 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.449 |
RANGRF | LONP2 | ENSP00000226105 | ENSP00000285737 | Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Belongs to the MOG1 family. | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. | 0.402 |
RANGRF | SH2D4B | ENSP00000226105 | ENSP00000345295 | Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Belongs to the MOG1 family. | SH2 domain containing 4B. | 0.428 |
RANGRF | UBOX5 | ENSP00000226105 | ENSP00000217173 | Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Belongs to the MOG1 family. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.433 |