FYB2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf226	CLBA1	ENSP00000413150	ENSP00000450114	Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226.	Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.	0.515
C1orf226	FYB2	ENSP00000413150	ENSP00000345972	Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226.	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	0.457
CFAP43	FYB2	ENSP00000349568	ENSP00000345972	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	0.441
CFAP43	MLF1	ENSP00000349568	ENSP00000376568	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus; Belongs to the MLF family.	0.439
CLBA1	C1orf226	ENSP00000450114	ENSP00000413150	Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.	Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226.	0.515
CLBA1	FYB2	ENSP00000450114	ENSP00000345972	Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	0.533
DNAJC13	EDRF1	ENSP00000260818	ENSP00000349244	DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.	Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.	0.521
DNAJC13	FYB2	ENSP00000260818	ENSP00000345972	DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	0.507
DNAJC13	MLF1	ENSP00000260818	ENSP00000376568	DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.	Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus; Belongs to the MLF family.	0.498
DNAJC13	NMT1	ENSP00000260818	ENSP00000468424	DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.	Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Belongs to the NMT family.	0.515
DNAJC13	TBCE-2	ENSP00000260818	ENSP00000495202	DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.	Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.	0.508
EDRF1	DNAJC13	ENSP00000349244	ENSP00000260818	Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.	DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex.	0.521
EDRF1	FYB2	ENSP00000349244	ENSP00000345972	Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	0.498
EDRF1	MLF1	ENSP00000349244	ENSP00000376568	Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.	Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus; Belongs to the MLF family.	0.498
EDRF1	NMT1	ENSP00000349244	ENSP00000468424	Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.	Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Belongs to the NMT family.	0.510
EDRF1	TBCE-2	ENSP00000349244	ENSP00000495202	Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.	Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.	0.515
FDFT1	FYB2	ENSP00000491537	ENSP00000345972	Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1; Belongs to the phytoene/squalene synthase family.	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	0.491
FYB2	C1orf226	ENSP00000345972	ENSP00000413150	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226.	0.457
FYB2	CFAP43	ENSP00000345972	ENSP00000349568	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.441
FYB2	CLBA1	ENSP00000345972	ENSP00000450114	FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.	Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.	0.533