node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C10orf55 | PLEKHB1 | ENSP00000409225 | ENSP00000346127 | Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55. | Pleckstrin homology domain containing B1. | 0.591 |
CRX | PLEKHB1 | ENSP00000221996 | ENSP00000346127 | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. Belongs to the paired homeobox family. | Pleckstrin homology domain containing B1. | 0.649 |
HECA | PLEKHB1 | ENSP00000356630 | ENSP00000346127 | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. | Pleckstrin homology domain containing B1. | 0.595 |
HECA | SELL | ENSP00000356630 | ENSP00000498227 | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. | 0.588 |
HECA | SELPLG | ENSP00000356630 | ENSP00000228463 | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. | 0.825 |
PLEK | PLEKHB1 | ENSP00000234313 | ENSP00000346127 | Pleckstrin; Major protein kinase C substrate of platelets. | Pleckstrin homology domain containing B1. | 0.542 |
PLEK | SELL | ENSP00000234313 | ENSP00000498227 | Pleckstrin; Major protein kinase C substrate of platelets. | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. | 0.440 |
PLEK2 | PLEKHB1 | ENSP00000216446 | ENSP00000346127 | Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. | Pleckstrin homology domain containing B1. | 0.592 |
PLEKHB1 | C10orf55 | ENSP00000346127 | ENSP00000409225 | Pleckstrin homology domain containing B1. | Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55. | 0.591 |
PLEKHB1 | CRX | ENSP00000346127 | ENSP00000221996 | Pleckstrin homology domain containing B1. | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. Belongs to the paired homeobox family. | 0.649 |
PLEKHB1 | HECA | ENSP00000346127 | ENSP00000356630 | Pleckstrin homology domain containing B1. | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. | 0.595 |
PLEKHB1 | PLEK | ENSP00000346127 | ENSP00000234313 | Pleckstrin homology domain containing B1. | Pleckstrin; Major protein kinase C substrate of platelets. | 0.542 |
PLEKHB1 | PLEK2 | ENSP00000346127 | ENSP00000216446 | Pleckstrin homology domain containing B1. | Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. | 0.592 |
PLEKHB1 | RAP1GDS1 | ENSP00000346127 | ENSP00000340454 | Pleckstrin homology domain containing B1. | Rap1 GTPase-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP- binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. | 0.614 |
PLEKHB1 | SELL | ENSP00000346127 | ENSP00000498227 | Pleckstrin homology domain containing B1. | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. | 0.589 |
PLEKHB1 | SELPLG | ENSP00000346127 | ENSP00000228463 | Pleckstrin homology domain containing B1. | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. | 0.667 |
PLEKHB1 | SYNGR4 | ENSP00000346127 | ENSP00000344041 | Pleckstrin homology domain containing B1. | Synaptogyrin-4; Synaptogyrin 4. | 0.646 |
PLEKHB1 | TEX26 | ENSP00000346127 | ENSP00000369840 | Pleckstrin homology domain containing B1. | Testis-expressed protein 26; Testis expressed 26. | 0.517 |
RAP1GDS1 | PLEKHB1 | ENSP00000340454 | ENSP00000346127 | Rap1 GTPase-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP- binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. | Pleckstrin homology domain containing B1. | 0.614 |
SELL | HECA | ENSP00000498227 | ENSP00000356630 | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. | 0.588 |