TMEM205 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRAMD1C	TMEM205	ENSP00000350881	ENSP00000346954	Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol [...]	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.470
HMOX2	TMEM205	ENSP00000477572	ENSP00000346954	Heme oxygenase 2; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.652
INSYN1	PROSER1	ENSP00000457205	ENSP00000332034	Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.	Proline and serine rich 1.	0.515
INSYN1	TMEM205	ENSP00000457205	ENSP00000346954	Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.470
PROSER1	INSYN1	ENSP00000332034	ENSP00000457205	Proline and serine rich 1.	Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.	0.515
PROSER1	TMEM205	ENSP00000332034	ENSP00000346954	Proline and serine rich 1.	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.525
PWP1	TMEM205	ENSP00000387365	ENSP00000346954	Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the epigenetic status of rDNA.	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.464
TMEM14A	TMEM205	ENSP00000211314	ENSP00000346954	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.660
TMEM14B	TMEM14C	ENSP00000420658	ENSP00000444561	Transmembrane protein 14B; Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.	Transmembrane protein 14C; Required for normal heme biosynthesis.	0.589
TMEM14B	TMEM205	ENSP00000420658	ENSP00000346954	Transmembrane protein 14B; Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.495
TMEM14C	TMEM14B	ENSP00000444561	ENSP00000420658	Transmembrane protein 14C; Required for normal heme biosynthesis.	Transmembrane protein 14B; Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.	0.589
TMEM14C	TMEM205	ENSP00000444561	ENSP00000346954	Transmembrane protein 14C; Required for normal heme biosynthesis.	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	0.479
TMEM205	GRAMD1C	ENSP00000346954	ENSP00000350881	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol [...]	0.470
TMEM205	HMOX2	ENSP00000346954	ENSP00000477572	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Heme oxygenase 2; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.	0.652
TMEM205	INSYN1	ENSP00000346954	ENSP00000457205	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.	0.470
TMEM205	PROSER1	ENSP00000346954	ENSP00000332034	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Proline and serine rich 1.	0.525
TMEM205	PWP1	ENSP00000346954	ENSP00000387365	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the epigenetic status of rDNA.	0.464
TMEM205	TMEM14A	ENSP00000346954	ENSP00000211314	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.	0.660
TMEM205	TMEM14B	ENSP00000346954	ENSP00000420658	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Transmembrane protein 14B; Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.	0.495
TMEM205	TMEM14C	ENSP00000346954	ENSP00000444561	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	Transmembrane protein 14C; Required for normal heme biosynthesis.	0.479