node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HOOK3 | OR52E4 | ENSP00000305699 | ENSP00000493085 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.490 |
HOOK3 | SPIDR | ENSP00000305699 | ENSP00000297423 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. | 0.436 |
HOOK3 | TRIM60 | ENSP00000305699 | ENSP00000497401 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | Tripartite motif containing 60; Belongs to the TRIM/RBCC family. | 0.405 |
HOOK3 | ZNF736 | ENSP00000305699 | ENSP00000400852 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.426 |
OR52E4 | HOOK3 | ENSP00000493085 | ENSP00000305699 | Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.490 |
OR52E4 | SPIDR | ENSP00000493085 | ENSP00000297423 | Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. | 0.544 |
OR52E4 | TRIM60 | ENSP00000493085 | ENSP00000497401 | Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Tripartite motif containing 60; Belongs to the TRIM/RBCC family. | 0.462 |
OR52E4 | ZNF736 | ENSP00000493085 | ENSP00000400852 | Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.485 |
SMIM8 | ZNF736 | ENSP00000376603 | ENSP00000400852 | Small integral membrane protein 8. | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.435 |
SPIDR | HOOK3 | ENSP00000297423 | ENSP00000305699 | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.436 |
SPIDR | OR52E4 | ENSP00000297423 | ENSP00000493085 | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. | Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.544 |
SPIDR | TRIM60 | ENSP00000297423 | ENSP00000497401 | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. | Tripartite motif containing 60; Belongs to the TRIM/RBCC family. | 0.406 |
SPIDR | ZNF736 | ENSP00000297423 | ENSP00000400852 | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.429 |
TRIM28 | ZNF736 | ENSP00000253024 | ENSP00000400852 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.559 |
TRIM60 | HOOK3 | ENSP00000497401 | ENSP00000305699 | Tripartite motif containing 60; Belongs to the TRIM/RBCC family. | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.405 |
TRIM60 | OR52E4 | ENSP00000497401 | ENSP00000493085 | Tripartite motif containing 60; Belongs to the TRIM/RBCC family. | Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.462 |
TRIM60 | SPIDR | ENSP00000497401 | ENSP00000297423 | Tripartite motif containing 60; Belongs to the TRIM/RBCC family. | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. | 0.406 |
TRIM60 | ZNF736 | ENSP00000497401 | ENSP00000400852 | Tripartite motif containing 60; Belongs to the TRIM/RBCC family. | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.608 |
UBTFL1 | ZNF736 | ENSP00000485108 | ENSP00000400852 | Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.450 |
ZNF736 | HOOK3 | ENSP00000400852 | ENSP00000305699 | Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.426 |