node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCAF4L2 | FAM49A | ENSP00000316496 | ENSP00000370724 | DDB1- and CUL4-associated factor 4-like protein 2; DDB1 and CUL4 associated factor 4 like 2. | Protein FAM49A; Belongs to the FAM49 family. | 0.418 |
DDX1 | FAM49A | ENSP00000370745 | ENSP00000370724 | ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double- strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 express [...] | Protein FAM49A; Belongs to the FAM49 family. | 0.473 |
DDX1 | MYCN | ENSP00000370745 | ENSP00000281043 | ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double- strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 express [...] | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | 0.791 |
FAM227B | FAM49A | ENSP00000299338 | ENSP00000370724 | Protein FAM227B; Family with sequence similarity 227 member B. | Protein FAM49A; Belongs to the FAM49 family. | 0.496 |
FAM49A | DCAF4L2 | ENSP00000370724 | ENSP00000316496 | Protein FAM49A; Belongs to the FAM49 family. | DDB1- and CUL4-associated factor 4-like protein 2; DDB1 and CUL4 associated factor 4 like 2. | 0.418 |
FAM49A | DDX1 | ENSP00000370724 | ENSP00000370745 | Protein FAM49A; Belongs to the FAM49 family. | ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double- strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 express [...] | 0.473 |
FAM49A | FAM227B | ENSP00000370724 | ENSP00000299338 | Protein FAM49A; Belongs to the FAM49 family. | Protein FAM227B; Family with sequence similarity 227 member B. | 0.496 |
FAM49A | FAM49B | ENSP00000370724 | ENSP00000429150 | Protein FAM49A; Belongs to the FAM49 family. | Protein FAM49B. | 0.698 |
FAM49A | LRATD1 | ENSP00000370724 | ENSP00000295092 | Protein FAM49A; Belongs to the FAM49 family. | Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. | 0.559 |
FAM49A | MYCN | ENSP00000370724 | ENSP00000281043 | Protein FAM49A; Belongs to the FAM49 family. | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | 0.506 |
FAM49A | PIK3C2G | ENSP00000370724 | ENSP00000445381 | Protein FAM49A; Belongs to the FAM49 family. | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity); Belongs to the PI3/PI4-kinase family. | 0.411 |
FAM49A | PPP1R1A | ENSP00000370724 | ENSP00000257905 | Protein FAM49A; Belongs to the FAM49 family. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.402 |
FAM49A | RHPN2 | ENSP00000370724 | ENSP00000254260 | Protein FAM49A; Belongs to the FAM49 family. | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. Belongs to the RHPN family. | 0.539 |
FAM49A | SPATS2L | ENSP00000370724 | ENSP00000482515 | Protein FAM49A; Belongs to the FAM49 family. | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. | 0.420 |
FAM49B | FAM49A | ENSP00000429150 | ENSP00000370724 | Protein FAM49B. | Protein FAM49A; Belongs to the FAM49 family. | 0.698 |
LRATD1 | FAM49A | ENSP00000295092 | ENSP00000370724 | Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. | Protein FAM49A; Belongs to the FAM49 family. | 0.559 |
LRATD1 | PPP1R1A | ENSP00000295092 | ENSP00000257905 | Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.467 |
MYCN | DDX1 | ENSP00000281043 | ENSP00000370745 | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double- strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 express [...] | 0.791 |
MYCN | FAM49A | ENSP00000281043 | ENSP00000370724 | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells. | Protein FAM49A; Belongs to the FAM49 family. | 0.506 |
PIK3C2G | FAM49A | ENSP00000445381 | ENSP00000370724 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity); Belongs to the PI3/PI4-kinase family. | Protein FAM49A; Belongs to the FAM49 family. | 0.411 |