node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OPTN | TARDBP | ENSP00000368022 | ENSP00000240185 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and [...] | TAR DNA-binding protein 43; RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondria [...] | 0.954 |
OPTN | UBQLN3 | ENSP00000368022 | ENSP00000347997 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and [...] | Ubiquilin-3; Ubiquilin 3. | 0.618 |
PSMD4 | RPS3A | ENSP00000357876 | ENSP00000346050 | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] | 40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. | 0.415 |
PSMD4 | UBQLN3 | ENSP00000357876 | ENSP00000347997 | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] | Ubiquilin-3; Ubiquilin 3. | 0.791 |
RPL19 | RPL23A | ENSP00000225430 | ENSP00000389103 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | 0.999 |
RPL19 | RPS18 | ENSP00000225430 | ENSP00000393241 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. | 0.999 |
RPL19 | RPS24 | ENSP00000225430 | ENSP00000414321 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.999 |
RPL19 | RPS25 | ENSP00000225430 | ENSP00000435096 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | Ribosomal protein S25. | 0.999 |
RPL19 | RPS26 | ENSP00000225430 | ENSP00000348849 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. | 0.999 |
RPL19 | RPS3A | ENSP00000225430 | ENSP00000346050 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. | 0.999 |
RPL19 | UBQLN3 | ENSP00000225430 | ENSP00000347997 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | Ubiquilin-3; Ubiquilin 3. | 0.626 |
RPL23A | RPL19 | ENSP00000389103 | ENSP00000225430 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.999 |
RPL23A | RPS18 | ENSP00000389103 | ENSP00000393241 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. | 0.999 |
RPL23A | RPS24 | ENSP00000389103 | ENSP00000414321 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | 40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.999 |
RPL23A | RPS25 | ENSP00000389103 | ENSP00000435096 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | Ribosomal protein S25. | 0.999 |
RPL23A | RPS26 | ENSP00000389103 | ENSP00000348849 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. | 0.999 |
RPL23A | RPS3A | ENSP00000389103 | ENSP00000346050 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | 40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. | 0.999 |
RPL23A | UBQLN3 | ENSP00000389103 | ENSP00000347997 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | Ubiquilin-3; Ubiquilin 3. | 0.608 |
RPS18 | RPL19 | ENSP00000393241 | ENSP00000225430 | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.999 |
RPS18 | RPL23A | ENSP00000393241 | ENSP00000389103 | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. | 0.999 |