node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATRAID | MXRA7 | ENSP00000484228 | ENSP00000465103 | All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.444 |
ATRAID | SUMF2 | ENSP00000484228 | ENSP00000498402 | All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.498 |
GRIN3B | MXRA7 | ENSP00000234389 | ENSP00000465103 | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.551 |
GUCY1B1 | MXRA7 | ENSP00000426786 | ENSP00000465103 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.595 |
METTL23 | MXRA7 | ENSP00000482599 | ENSP00000465103 | Methyltransferase-like protein 23; Probable methyltransferase. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.469 |
MXRA7 | ATRAID | ENSP00000465103 | ENSP00000484228 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. | 0.444 |
MXRA7 | GRIN3B | ENSP00000465103 | ENSP00000234389 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. | 0.551 |
MXRA7 | GUCY1B1 | ENSP00000465103 | ENSP00000426786 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.595 |
MXRA7 | METTL23 | ENSP00000465103 | ENSP00000482599 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Methyltransferase-like protein 23; Probable methyltransferase. | 0.469 |
MXRA7 | MXRA8 | ENSP00000465103 | ENSP00000399229 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Matrix remodeling-associated protein 8; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By [...] | 0.554 |
MXRA7 | SUMF2 | ENSP00000465103 | ENSP00000498402 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.463 |
MXRA7 | TMEM161B | ENSP00000465103 | ENSP00000426354 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Transmembrane protein 161B; Belongs to the TMEM161 family. | 0.529 |
MXRA8 | MXRA7 | ENSP00000399229 | ENSP00000465103 | Matrix remodeling-associated protein 8; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By [...] | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.554 |
SUMF2 | ATRAID | ENSP00000498402 | ENSP00000484228 | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. | 0.498 |
SUMF2 | MXRA7 | ENSP00000498402 | ENSP00000465103 | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.463 |
SUMF2 | TMEM161B | ENSP00000498402 | ENSP00000426354 | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | Transmembrane protein 161B; Belongs to the TMEM161 family. | 0.442 |
TMEM161B | MXRA7 | ENSP00000426354 | ENSP00000465103 | Transmembrane protein 161B; Belongs to the TMEM161 family. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.529 |
TMEM161B | SUMF2 | ENSP00000426354 | ENSP00000498402 | Transmembrane protein 161B; Belongs to the TMEM161 family. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.442 |