STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MXRA7Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 (204 aa)    
Predicted Functional Partners:
METTL23
Methyltransferase-like protein 23; Probable methyltransferase
      
 0.801
MXRA8
Matrix remodeling-associated protein 8; May play a role in the maturation and maintenance of blood-brain barrier; V-set domain containing
   
  
 0.737
PRPSAP1
Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis
      
 0.699
ST6GALNAC2
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Sialyltransferases
      
 0.679
B4GALNT4
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family
   
  
 0.673
RHBDF2
Inactive rhomboid protein 2; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity); Belongs to the peptidase S54 family
      
 0.632
ENSG00000267168
Uncharacterized protein
      
 0.581
C1QTNF4
Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related
      
 0.573
PRPSAP2
Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis
      
 0.530
JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an argi [...]
      
 0.528
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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