| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM20C | MXRA7 | ENSP00000322323 | ENSP00000465103 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.476 |
| FAM20C | MXRA8 | ENSP00000322323 | ENSP00000399229 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | Matrix remodeling-associated protein 8; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By [...] | 0.550 |
| GRIN3B | MXRA7 | ENSP00000234389 | ENSP00000465103 | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.812 |
| GUCY1B1 | MXRA7 | ENSP00000426786 | ENSP00000465103 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.891 |
| MAPT | MXRA7 | ENSP00000340820 | ENSP00000465103 | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its st [...] | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.456 |
| MAPT | SEC63 | ENSP00000340820 | ENSP00000357998 | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its st [...] | Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin- 1 biogenesis and trafficking to the plasma membrane of the primary [...] | 0.473 |
| METTL23 | MFSD11 | ENSP00000482599 | ENSP00000464932 | Methyltransferase-like protein 23; Probable methyltransferase. | UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family. | 0.538 |
| METTL23 | MXRA7 | ENSP00000482599 | ENSP00000465103 | Methyltransferase-like protein 23; Probable methyltransferase. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.498 |
| MFSD11 | METTL23 | ENSP00000464932 | ENSP00000482599 | UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family. | Methyltransferase-like protein 23; Probable methyltransferase. | 0.538 |
| MFSD11 | MXRA7 | ENSP00000464932 | ENSP00000465103 | UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family. | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | 0.529 |
| MXRA7 | FAM20C | ENSP00000465103 | ENSP00000322323 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | 0.476 |
| MXRA7 | GRIN3B | ENSP00000465103 | ENSP00000234389 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. | 0.812 |
| MXRA7 | GUCY1B1 | ENSP00000465103 | ENSP00000426786 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.891 |
| MXRA7 | MAPT | ENSP00000465103 | ENSP00000340820 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its st [...] | 0.456 |
| MXRA7 | METTL23 | ENSP00000465103 | ENSP00000482599 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Methyltransferase-like protein 23; Probable methyltransferase. | 0.498 |
| MXRA7 | MFSD11 | ENSP00000465103 | ENSP00000464932 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family. | 0.529 |
| MXRA7 | MXRA8 | ENSP00000465103 | ENSP00000399229 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Matrix remodeling-associated protein 8; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By [...] | 0.646 |
| MXRA7 | SEC63 | ENSP00000465103 | ENSP00000357998 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin- 1 biogenesis and trafficking to the plasma membrane of the primary [...] | 0.437 |
| MXRA7 | SUMF2 | ENSP00000465103 | ENSP00000498402 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.425 |
| MXRA7 | TMEM161B | ENSP00000465103 | ENSP00000426354 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7. | Transmembrane protein 161B; Belongs to the TMEM161 family. | 0.438 |
