C14orf178 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCK1	C14orf178	ENSP00000238561	ENSP00000348145	AarF domain-containing protein kinase 1; Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase- independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT. The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	0.439
C10orf55	C14orf178	ENSP00000409225	ENSP00000348145	Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55.	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	0.588
C10orf55	C5orf38	ENSP00000409225	ENSP00000334267	Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55.	Protein CEI; Chromosome 5 open reading frame 38.	0.442
C10orf55	C6orf223	ENSP00000409225	ENSP00000426159	Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55.	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223.	0.479
C14orf178	ADCK1	ENSP00000348145	ENSP00000238561	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	AarF domain-containing protein kinase 1; Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase- independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT. The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).	0.439
C14orf178	C10orf55	ENSP00000348145	ENSP00000409225	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55.	0.588
C14orf178	C5orf38	ENSP00000348145	ENSP00000334267	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Protein CEI; Chromosome 5 open reading frame 38.	0.442
C14orf178	C6orf223	ENSP00000348145	ENSP00000426159	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223.	0.495
C14orf178	ISM2	ENSP00000348145	ENSP00000341490	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Isthmin-2; Isthmin 2.	0.438
C14orf178	NOXRED1	ENSP00000348145	ENSP00000370215	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase.	0.593
C14orf178	SAMD15	ENSP00000348145	ENSP00000216471	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Sterile alpha motif domain containing 15.	0.580
C14orf178	SETX	ENSP00000348145	ENSP00000224140	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Probable helicase senataxin; Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G- rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA [...]	0.575
C14orf178	TMED8	ENSP00000348145	ENSP00000216468	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Protein TMED8; Transmembrane p24 trafficking protein family member 8.	0.504
C14orf178	TMEM170B	ENSP00000348145	ENSP00000368737	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.550
C5orf38	C10orf55	ENSP00000334267	ENSP00000409225	Protein CEI; Chromosome 5 open reading frame 38.	Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55.	0.442
C5orf38	C14orf178	ENSP00000334267	ENSP00000348145	Protein CEI; Chromosome 5 open reading frame 38.	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	0.442
C6orf223	C10orf55	ENSP00000426159	ENSP00000409225	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223.	Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55.	0.479
C6orf223	C14orf178	ENSP00000426159	ENSP00000348145	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223.	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	0.495
ISM2	C14orf178	ENSP00000341490	ENSP00000348145	Isthmin-2; Isthmin 2.	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	0.438
NOXRED1	C14orf178	ENSP00000370215	ENSP00000348145	NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase.	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	0.593