node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOX1 | KCNRG | ENSP00000263182 | ENSP00000324191 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. | 0.465 |
BBOX1 | TRAT1 | ENSP00000263182 | ENSP00000295756 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.980 |
BBOX1 | TRIM13 | ENSP00000263182 | ENSP00000348299 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] | 0.648 |
CD5 | JAG2 | ENSP00000342681 | ENSP00000328169 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). | 0.559 |
CD5 | KCNRG | ENSP00000342681 | ENSP00000324191 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. | 0.424 |
CD5 | TRAT1 | ENSP00000342681 | ENSP00000295756 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.591 |
CD5 | TRIM13 | ENSP00000342681 | ENSP00000348299 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] | 0.735 |
JAG2 | CD5 | ENSP00000328169 | ENSP00000342681 | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | 0.559 |
JAG2 | PSENEN | ENSP00000328169 | ENSP00000468411 | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. Belongs to the PEN-2 family. | 0.575 |
JAG2 | TRIM13 | ENSP00000328169 | ENSP00000348299 | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] | 0.779 |
KCNRG | BBOX1 | ENSP00000324191 | ENSP00000263182 | Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | 0.465 |
KCNRG | CD5 | ENSP00000324191 | ENSP00000342681 | Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | 0.424 |
KCNRG | TRAT1 | ENSP00000324191 | ENSP00000295756 | Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.547 |
KCNRG | TRIM13 | ENSP00000324191 | ENSP00000348299 | Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] | 0.937 |
NTS | PDYN | ENSP00000256010 | ENSP00000440185 | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family. | Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect; Belongs to the opioid neuropeptide precursor family. | 0.912 |
NTS | TRIM13 | ENSP00000256010 | ENSP00000348299 | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family. | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] | 0.665 |
PDYN | NTS | ENSP00000440185 | ENSP00000256010 | Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect; Belongs to the opioid neuropeptide precursor family. | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family. | 0.912 |
PDYN | PSENEN | ENSP00000440185 | ENSP00000468411 | Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect; Belongs to the opioid neuropeptide precursor family. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. Belongs to the PEN-2 family. | 0.570 |
PDYN | TRIM13 | ENSP00000440185 | ENSP00000348299 | Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect; Belongs to the opioid neuropeptide precursor family. | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] | 0.859 |
PSENEN | JAG2 | ENSP00000468411 | ENSP00000328169 | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. Belongs to the PEN-2 family. | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). | 0.575 |