node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPATCH1 | LEKR1 | ENSP00000170564 | ENSP00000474182 | G-patch domain containing 1; Belongs to the GPATCH1 family. | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | 0.437 |
LEKR1 | GPATCH1 | ENSP00000474182 | ENSP00000170564 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | G-patch domain containing 1; Belongs to the GPATCH1 family. | 0.437 |
LEKR1 | NUP107 | ENSP00000474182 | ENSP00000229179 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | 0.423 |
LEKR1 | NUP153 | ENSP00000474182 | ENSP00000444029 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.426 |
LEKR1 | NUP155 | ENSP00000474182 | ENSP00000231498 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | 0.431 |
LEKR1 | NUP205 | ENSP00000474182 | ENSP00000285968 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC. | 0.450 |
LEKR1 | NUP85 | ENSP00000474182 | ENSP00000245544 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3- kinase-Rac-lammellipodium protrusion cascade. Inv [...] | 0.454 |
LEKR1 | PLEKHG4 | ENSP00000474182 | ENSP00000353646 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. | 0.413 |
LEKR1 | SEH1L | ENSP00000474182 | ENSP00000382779 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore; Belongs to the WD repeat SEC13 family. | 0.473 |
LEKR1 | SLC66A1L | ENSP00000474182 | ENSP00000413228 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Putative uncharacterized protein SLC66A1L; Solute carrier family 66 member 1 like. | 0.442 |
LEKR1 | ZNF829 | ENSP00000474182 | ENSP00000428679 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | Zinc finger protein 829; May be involved in transcriptional regulation. | 0.422 |
NUP107 | LEKR1 | ENSP00000229179 | ENSP00000474182 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | 0.423 |
NUP107 | NUP153 | ENSP00000229179 | ENSP00000444029 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.999 |
NUP107 | NUP155 | ENSP00000229179 | ENSP00000231498 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | 0.999 |
NUP107 | NUP205 | ENSP00000229179 | ENSP00000285968 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC. | 0.999 |
NUP107 | NUP85 | ENSP00000229179 | ENSP00000245544 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3- kinase-Rac-lammellipodium protrusion cascade. Inv [...] | 0.999 |
NUP107 | SEH1L | ENSP00000229179 | ENSP00000382779 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore; Belongs to the WD repeat SEC13 family. | 0.999 |
NUP153 | LEKR1 | ENSP00000444029 | ENSP00000474182 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1. | 0.426 |
NUP153 | NUP107 | ENSP00000444029 | ENSP00000229179 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | 0.999 |
NUP153 | NUP155 | ENSP00000444029 | ENSP00000231498 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | 0.996 |