FAM180B protein (human) - STRING interaction network

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FAM180B

Protein FAM180B; Family with sequence similarity 180 member B. (183 aa)

Predicted Functional Partners:

SLC39A13

0.604

C1QTNF4

0.549

SLC24A4

0.474

NYAP1

0.447

GAGE12H

0.446

GAGE12D

0.446

MTHFD1L

0.445

CLUL1

0.439

SUCLG2

0.428

BNIP5

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNIP5	FAM180B	ENSP00000418983	ENSP00000443133	BCL2 interacting protein 5.	Protein FAM180B; Family with sequence similarity 180 member B.	0.418
BNIP5	GAGE12H	ENSP00000418983	ENSP00000371141	BCL2 interacting protein 5.	G antigen 12H.	0.571
C1QTNF4	FAM180B	ENSP00000302274	ENSP00000443133	Complement C1q tumor necrosis factor-related protein 4; May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).	Protein FAM180B; Family with sequence similarity 180 member B.	0.549
CLUL1	FAM180B	ENSP00000441726	ENSP00000443133	Clusterin-like protein 1; Clusterin like 1.	Protein FAM180B; Family with sequence similarity 180 member B.	0.439
FAM180B	BNIP5	ENSP00000443133	ENSP00000418983	Protein FAM180B; Family with sequence similarity 180 member B.	BCL2 interacting protein 5.	0.418
FAM180B	C1QTNF4	ENSP00000443133	ENSP00000302274	Protein FAM180B; Family with sequence similarity 180 member B.	Complement C1q tumor necrosis factor-related protein 4; May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).	0.549
FAM180B	CLUL1	ENSP00000443133	ENSP00000441726	Protein FAM180B; Family with sequence similarity 180 member B.	Clusterin-like protein 1; Clusterin like 1.	0.439
FAM180B	GAGE12D	ENSP00000443133	ENSP00000384214	Protein FAM180B; Family with sequence similarity 180 member B.	G antigen 12D.	0.446
FAM180B	GAGE12H	ENSP00000443133	ENSP00000371141	Protein FAM180B; Family with sequence similarity 180 member B.	G antigen 12H.	0.446
FAM180B	MTHFD1L	ENSP00000443133	ENSP00000478253	Protein FAM180B; Family with sequence similarity 180 member B.	Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.	0.445
FAM180B	NYAP1	ENSP00000443133	ENSP00000300179	Protein FAM180B; Family with sequence similarity 180 member B.	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Belongs to the NYAP family.	0.447
FAM180B	SLC24A4	ENSP00000443133	ENSP00000431840	Protein FAM180B; Family with sequence similarity 180 member B.	Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	0.474
FAM180B	SLC39A13	ENSP00000443133	ENSP00000354689	Protein FAM180B; Family with sequence similarity 180 member B.	Zinc transporter ZIP13; Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family.	0.604
FAM180B	SUCLG2	ENSP00000443133	ENSP00000419325	Protein FAM180B; Family with sequence similarity 180 member B.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.428
GAGE12D	FAM180B	ENSP00000384214	ENSP00000443133	G antigen 12D.	Protein FAM180B; Family with sequence similarity 180 member B.	0.446
GAGE12H	BNIP5	ENSP00000371141	ENSP00000418983	G antigen 12H.	BCL2 interacting protein 5.	0.571
GAGE12H	FAM180B	ENSP00000371141	ENSP00000443133	G antigen 12H.	Protein FAM180B; Family with sequence similarity 180 member B.	0.446
MTHFD1L	FAM180B	ENSP00000478253	ENSP00000443133	Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.	Protein FAM180B; Family with sequence similarity 180 member B.	0.445
MTHFD1L	SLC24A4	ENSP00000478253	ENSP00000431840	Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.	Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	0.421
MTHFD1L	SUCLG2	ENSP00000478253	ENSP00000419325	Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.508