STRINGSTRING
DCHS2 protein (human) - STRING interaction network
"DCHS2" - Dachsous 2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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DCHS2Dachsous 2 (Drosophila); Calcium-dependent cell-adhesion protein (2916 aa)    
Predicted Functional Partners:
JUP
Junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] (745 aa)
     
 
  0.806
CTNNB1
Catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] (781 aa)
     
 
  0.796
CTNND2
Catenin (cadherin-associated protein), delta 2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed-25807484). Involved in the regulation of Wnt signaling (PubMed-25807484). It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating ad [...] (1225 aa)
     
 
  0.778
CTNND1
Catenin (cadherin-associated protein), delta 1; Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage (968 aa)
     
 
  0.770
ARVCF
Armadillo repeat gene deleted in velocardiofacial syndrome; Involved in protein-protein interactions at adherens junctions (962 aa)
     
 
  0.761
PKP4
Plakophilin 4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (1192 aa)
     
 
  0.759
PKP3
Plakophilin 3; May play a role in junctional plaques (797 aa)
     
 
  0.662
PKP1
Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis (747 aa)
     
 
  0.662
PKP2
Plakophilin 2; May play a role in junctional plaques (881 aa)
     
 
  0.662
UPRT
Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) (309 aa)
       
 
  0.657
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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